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Wagaskar et al. Mini-invasive Surg 2022;6:14 Mini-invasive Surgery
DOI: 10.20517/2574-1225.2021.106

Review Open Access

Oligometastatic prostate cancer: a new horizon for

robotic radical prostatectomy

1,2
1
4,5
3
Vinayak G. Wagaskar , Flora Barthe , Alberto Martini , Prasanna Sooriakumaran , Ash Tewari 1
1
Department of Urology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
2
The Urology, Andrology, Renal Transplant Unit, Hospital Pasteur 2, Nice 06000, France.
3
Department of Urology, Urological Research Institute, Vita-Salute University, San Raffaele Scientific Institute, Milan 20132, Italy.
4
Department of Urology, Cleveland Clinic London, London NW3 2QG, UK.
5
Department of Urology, University College London Hospitals NHS Foundation Trust, London NW3 2QG, UK.
Correspondence to: Dr. Vinayak G. Wagaskar, Department of Urology, Icahn School of Medicine at Mount Sinai Hospital, 1425
Madison Avenue, New York, NY 10029, USA. E-mail: vinayak.wagaskar@mountsinai.org
How to cite this article: Wagaskar VG, Barthe F, Martini A, Sooriakumaran P, Tewari A. Oligometastatic prostate cancer: a new
horizon for robotic radical prostatectomy. Mini-invasive Surg 2022;6:14. https://dx.doi.org/10.20517/2574-1225.2021.106
Received: 1 Sep 2021 First Decision: 18 Oct 2021 Revised: 23 Dec 2021 Accepted: 29 Jan 2022 Published: 8 Mar 2022
Academic Editor: Giulio Belli Copy Editor: Xi-Jun Chen Production Editor: Xi-Jun Chen

Abstract
The advent of modern diagnostic techniques and improved patient monitoring in the setting of clinical trials has led
to an increased diagnosis of oligometastatic prostate cancer (OMPC), defined as three-to-five metastatic deposits
in a single organ or multiple organs. OMPC is increasingly diagnosed in men who were in the past considered to
have organ-confined disease. OMPC occurs at the transition between localized prostate cancer and widespread
metastases. Our review evaluates the available evidence regarding robot-assisted cytoreductive prostatectomy
feasibility and oncological outcomes in oligometastatic settings. We also consider the limitations and future
directions for this approach. We performed a non-systematic PubMed and Google Scholar search. We screened
pertinent studies published from 2014 up to May 2021. Our search identified 524 records. After excluding
duplication, 54 full-text articles were identified and were screened for eligibility. We found nine papers (863
patients) that met the inclusion criteria for the review. The outcomes evaluated were 1-, 3-, and 5-year
progression-free survival, cancer-specific and overall survival rates. Our review article demonstrates the feasibility
and safety of Robot-assisted radical prostatectomy in patients with OMPC with proven oncological benefits.
Prospective studies are ongoing and may provide further solid evidence.

Keywords: Oligometastatic prostate cancer, robotic radical prostatectomy, metastatic prostate cancer, localized
prostate cancer

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
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