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Wagaskar et al. Mini-invasive Surg 2022;6:14 https://dx.doi.org/10.20517/2574-1225.2021.106 Page 3 of 8
Figure 1. Flow chart.
Definition of progression
PFS was defined as the time from starting androgen deprivation therapy to the evidence of biochemical or
clinical progression. Biochemical progression was defined as two consecutive PSA readings ≥ 0.2 ng/mL
separated by 2-week intervals if PSA decreased to undetectable serum levels postoperatively. Clinical
progression was determined as the onset of new symptoms due to local progression or distant metastases.
CSS was defined as the time from prostate cancer diagnosis to death related to prostate cancer events. OS
was defined as the time from prostate cancer diagnosis to death from any noncancer-related cause.
