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M’Harzi et al . Mini-invasive Surg 2019;3:27 Mini-invasive Surgery
DOI: 10.20517/2574-1225.2019.22

Technical Note Open Access

One anastomosis gastric bypass and
esojejunostomy in rats: surgical techniques

Leila M’Harzi , Matthieu Bruzzi 1,2,3 , Jean-Marc Chevallier 1,2,3 , Richard Douard 1,2,3
1,2
1 General and Digestive Surgery Unit, Georges Pompidou, AP-HP University Hospital, Paris 75908, France.
2 INSERM 970, Équipe 2, PARCC, HEGP, Paris 75015, France.
3 Paris Descartes Faculty of Medicine, Paris 75006, France.
Correspondence to: Dr. Matthieu Bruzzi, Service de chirurgie digestive, Hôpital européen Georges Pompidou, 20 Rue Leblanc,
Paris 75908, France. E-mail: matthieu.bruzzi@aphp.fr
How to cite this article: M’Harzi L, Bruzzi M, Chevallier JM, Douard R. One anastomosis gastric bypass and esojejunostomy in
rats: surgical techniques. Mini-invasive Surg 2019;3:27. http://dx.doi.org/10.20517/2574-1225.2019.22
Received: 16 Jul 2019 First Decision: 27 Aug 2019 Revised: 12 Sep 2019 Accepted: 17 Sep 2019 Published: 23 Sep 2019

Science Editor: Wah Yang Copy Editor: Cai-Hong Wang Production Editor: Tian Zhang

Abstract
One anastomosis gastric bypass (OAGB) is a popular bariatric procedure, but controversies remain regarding biliary
reflux and the potential risk of cancer. Esophagojejunostomy (EJ) in rats is a validated and reproducible model for the
development of metaplasia [Barett’s esophagus (BE)] and esophageal adenocarcinoma (EA) with a minimal exposure
of 12 to 20 weeks. We are analyzing the risks of BE and EA in an OAGB rat model and comparing these with the EJ rat
model. The purpose of this study is to describe our OAGB and EJ techniques in rats that we used to evaluate biliary reflux
and share our experience with scientists and the bariatric community. These operations are short and simple procedures
with acceptable morbidity.

Keywords: Mini-gastric bypass, biliary reflux, cancer

INTRODUCTION
One anastomosis gastric bypass (OAGB), or mini-gastric bypass, is a popular bariatric surgery procedure
[1-3]
in humans , but controversies remain regarding the risks of biliary reflux and potential complications as
[4]
metaplasia, dysplasia and cancer .
No studies on the risks of these for humans are currently available and research, including experimental
[4,5]
studies, is needed to help answer this important question . The risk of developing metaplasia [Barett’s
esophagus (BE)] or esophageal adenocarcinoma (EA) after omega loop montage mainly exists because of

© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0
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