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[8]
group prompts us to now evaluate OAGB and its consequences using 30-week and 50-week follow-ups
and compare these results to EJ surgeries (control group).

On the day of sacrifices, histology and molecular analysis on esophageal and gastric mucosae can be
[5]
performed to analyze the prevalence of BE and cancer .

Concerning the esophagus, the absence of metaplasia, dysplasia or cancer in the OAGB group compared
with the EJ group will suggest confer a real protective effect of the long gastric tube used in the OAGB
model. Conversely, the presence of precancerous or cancerous lesions in the esogastric blocs of OAGB rats
gives additional arguments to detractors of the technique to decrease its diffusion.

This short communication is a simple contribution for researchers interested in the topic of biliary reflux
after OAGB because there is an urgent need to answer this specific issue, especially for patients who have
already undergone surgery.

DECLARATIONS
Acknowledgments
We thank the assistance of INSERM U970, ERI in the study.

Authors’ contributions
Project development: Bruzzi M, Chevallier JM, Douard R
Surgery and data Collection: M’Harzi L, Bruzzi M
Wrote the manuscript: M’Harzi L, Bruzzi M
Comment: Chevallier JM, Douard R

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
All applicable institutional and/or national guidelines for the care and use of animals were followed. All
experiments were performed in compliance with the European Community guidelines and approved by
the Institutional Animal Care and Use Committee.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

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3. Rutledge R. The mini-gastric bypass: experience with the first 1,274 cases. Obes Surg 2001;11:276-80.