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Ciria et al. Mini-invasive Surg 2024;8:10  https://dx.doi.org/10.20517/2574-1225.2023.126  Page 7 of 9

               Second stage
               Similarly to classic ALPPS, a CT scan on days 10-14 after the first procedure to check volumetric status is
               performed. If adequate remnant volume is achieved, the procedure is finalized by a laparoscopic right
               hepatectomy or right trisectionectomy. In case of insufficient liver hypertrophy, the embolization of right
               hepatic vein or both middle and right hepatic vein to obtain a complete Liver venous deprivation (or
               “double vein embolization”) may be performed to increase FLR. In case of insufficient liver hypertrophy or
               disease progression, the tourniquet should ideally be removed by a minimally invasive approach. Blunt
               dissection and the use of saline irrigation may facilitate removal of adhesions during tourniquet removal.
               However, this procedure should not be underestimated as iatrogenic injury may occur during surgery. In
               our experience, we only had to remove one tourniquet and there were no incidences.


               The positioning and access trocars are the same as those used in the first stage. In the liver surface, the tape
               and the knot will be observed. By releasing the knot, an ischemic line is observed and transection in this
               area becomes easier. The tape is employed to perform a hanging maneuver that facilitates the transection
               plane. By pulling up the tape, access to the transection plane is easily gained towards the anterior surface of
               the inferior vena cava (IVC). However, it should noted that the tape may cause tight adhesions in the
               anterior surface of IVC that might be dissected with caution. The last step includes hepatic veins and
               Glissonean pedicles section using endostaplers.


               CONCLUSION
               MI-ALPPS is a technique with a high degree of complexity and must be performed by surgeons with
               expertise in MILS. The preliminary evidence suggests that it may be safe with a lower morbidity and
               mortality rate relative to open series. However, the number of series is limited, and caution should be taken
               to get powerful conclusions regarding the application of this technique.


               DECLARATIONS
               Authors’ contributions
               Conception and design of the study: Ciria R
               Data review: Durán M, Calleja R, Pérez-de-Villar JM
               Draft manuscript preparation: Durán M, Calleja R, Pérez-de-Villar JM
               Critical review: Ciria R, Briceño J
               All authors reviewed the results and approved the final version of the manuscript.


               Availability of data and materials
               Not applicable.

               Financial support and sponsorship
               None.

               Conflicts of interest
               All authors declared that there are no conflicts of interest.

               Ethical approval and consent to participate
               As this is a technical review article and no patient data is presented, it did not need to be submitted to an
               ethics committee. Informed consent was obtained from the patient for the publication of the images.


               Consent for publication
               Not applicable.
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