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Vojdeman et al. J Transl Genet Genom 2021;5:182-88 Journal of Translational
DOI: 10.20517/jtgg.2021.03
Genetics and Genomics

Original Article Open Access

B-cell receptor stereotyped subsets and outcome for
patients with chronic lymphocytic leukemia in the

HOVON 68 trial

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Fie J. Vojdeman , Lone B. Pedersen , Doreen te Raa , Vesa Juvonen , Yvette van Norden , Geir E.
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Tjønnfjord , Eva Kimby , Maija Itälä-Remes , Richard Rosenquist , Anton W. Langerak , Ludo M. Evers ,
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Thorsten Zenz , Jan Walewski , Marinus H. J. van Oers , Christian H. Geisler , Arnon P. Kater , Carsten U.
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Niemann , HOVON 68 trial group
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Department of Clinical Biochemistry, Zealand University Hospital, Roskilde DK-4000, Denmark.
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Department of Hematology, Rigshospitalet, Copenhagen DK-2100, Denmark.
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Department of Hematology, Amsterdam Medical Center, University of Amsterdam, Amsterdam 1105, AZ, The Netherlands.
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Department of Clinical Chemistry and Laboratory Division, Turku University Hospital, Turku 20521, Finland.
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HOVON Data Centre, Department of Hematology, Erasmus MC, Rotterdam, 3015 GD, The Netherlands.
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Department of Haematology, Oslo University Hospital, KG Jebsen Centre for B-cell malignancies, and Institute of Clinical
Medicine, University of Oslo, Oslo 0372, Norway.
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Division of Hematology, Department of Medicine at Huddinge, Karolinska Institute, Stockholm 17177, Sweden.
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Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17177, Sweden.
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Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, 3015 GD, The Netherlands.
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Department of Medical Oncology and Haematology, University Hospital Zurich and University of Zurich, Zurich CH-8006,
Switzerland; Department of Molecular Therapy in Haematology & Oncology, NCT/DKFZ, Heidelberg 69120, Germany.
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Department of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02781,
Poland.
Correspondence to: Dr. Fie J. Vojdeman, Department of Clinical Biochemistry, Zealand University Hospital, Sygehusvej 10,
Roskilde DK-4000, Denmark. E-mail: fiv@regionsjaelland.dk
How to cite this article: Vojdeman FJ, Pedersen LB, te Raa D, Juvonen V, van Norden Y, Tjønnfjord GE, Kimby E, Itälä-Remes M,
Rosenquist R, Langerak AW, Evers LM, Zenz T, Walewski J, van Oers MHJ, Geisler CH, Kater AP, Niemann CU, HOVON 68 trial
group. B-cell receptor stereotyped subsets and outcome for patients with chronic lymphocytic leukemia in the HOVON 68 trial. J
Transl Genet Genom 2021;5:182-88. https://dx.doi.org/10.20517/jtgg.2021.03
Received: 26 Feb 2021 First Decision: 28 Apr 2021 Revised: 1 May 2021 Accepted: 2 Jun 2021 First online: 8 Jun 2021
Academic Editor: Susan L. Slager Copy Editor: Xi-Jun Chen Production Editor: Xi-Jun Chen
Abstract
Aim: We here assessed the impact of B-cell receptor stereotypy on progression-free survival (PFS) and overall
survival in patients from the HOVON 68 trial.
© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
indicate if changes were made.

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