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Donskov et al. J Transl Genet Genom 2021;5:136-62 https://dx.doi.org/10.20517/jtgg.2021.12 Page 9

Table 1. Summary of the genetic/epigenetic associations of NTC genes to psychiatric disorders

Interacting NR coregulators HRE gene
Gene Gene
Family Gene name GWAS WES MWAS GWAS catalogue GWAS set
symbol synonym GWAS WES MWAS
catalogue association
0B Short heterodimeric NR0B2 SHP BBX (SZ), BRMS1 SIN3A (ASD)
partner (BPD)
0B Dosage-sensitive sex NR0B1 DAX1 SZ
reversal-adrenal
hypoplasia congenital
critical region on the X
chromosome, Gene 1

1A Thyroid hormone NR1A1 THRA EP300 NCOA1 NCOR2 MGMT (anorexia MDD
receptor-α (CD/SZ/MDD), (ASD) (SZ) nervosa), NCOR2
NRIP1 (SZ) (cocaine
dependence),
TBL1Y (ASD)

1A Thyroid hormone NR1A2 THRB SZ, MDD in trauma-unexposed EP300 NCOA1 NCOR2 MGMT (anorexia
receptor-β individuals, general cognitive ability, (CD/SZ/MDD), (ASD) (SZ) nervosa), NCOR2
intelligence NRIP1 (SZ) (cocaine
dependence),
TBL1Y (ASD)
1B Retinoic acid receptor-α NR1B1 RARA EP300 NCOA1 NCOR2 MGMT (anorexia
(CD/SZ/MDD), (ASD) (SZ) nervosa), NCOR2
NRIP1 (SZ) (cocaine
dependence),
TBL1Y (ASD)
1B Retinoic acid receptor-β NR1B2 RARB Oppositional defiant disorder EP300 NCOA1 NCOR2 NCOR2 (cocaine MDD
dimensions in ADHD (CD/SZ/MDD), (ASD) (SZ) dependence),
NRIP1 (SZ) TBL1Y (ASD)

1B Retinoic acid receptor-γ NR1B3 RARG SZ BPD or attention deficit hyperactivity EP300 NCOA1 NCOR2 MGMT (anorexia
disorder, personality traits in BPD (CD/SZ/MDD), (ASD) (SZ) nervosa), NCOR2
NRIP1 (SZ) (cocaine
dependence),
TBL1Y (ASD)
1C Peroxisome proliferator- NR1C1 PPARA SZ EP300 NCOA1 NCOR2 NCOR2 (cocaine
activated receptor-α (CD/SZ/MDD), (ASD) (SZ) dependence),
NRIP1 (SZ) TBL1Y (ASD)
1C Peroxisome proliferator- NR1C2 PPARD MDD Response to antipsychotic treatment EP300 NCOA1 NCOR2
activated receptor-δ (CD/SZ/MDD), (ASD) (SZ)
NRIP1 (SZ)

1C Peroxisome proliferator- NR1C3 PPARG EP300 CREBBP NCOR2 MGMT (anorexia ASD
activated receptor-γ (CD/SZ/MDD), (ASD), (SZ) nervosa), NCOR2
NRIP1 (SZ) NCOA1 (cocaine
(ASD) dependence),