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Page 324 Genvigir et al. J Transl Genet Genom 2020;4:320-55 I http://dx.doi.org/10.20517/jtgg.2020.37

Ref. [22] [21] [22] [27] [29] [30] [24]

Clinical outcomes No association of CES1 356C>T variant with AR No association of CES2 -1548A>G, 4595A>G and 8721C>T variants with AR or diarrhea CES2 8721TT genotype was associated with increased risk of AR No association of CYP2C8 rs11572076 variant with leukopenia CYP2C8 rs11572076GG genotype was associated with reduced risk of leukopenia. No association with AR, diarrhea, or anemia CYP2C8*3 variant was associated with

Pharmacokinetics No association of CES2 -1548A>G, 4595A>G and 8721C>T variants with MPA pharmacokinetics No association of CYP2C8*3 variant with

- - - - - MPA C/D
Immunosuppressive regimen MMF Cyclosporine Tacrolimus Sirolimus Corticosteroids MMF Tacrolimus Corticosteroids At day 28 MMF Cyclosporine Tacrolimus Sirolimus Corticosteroids MMF Cyclosporine Tacrolimus Sirolimus Corticosteroids One-year follow-up EC-MPS Cyclosporine Corticosteroids Six-month follow-up EC-MPS Tacrolimus Corticosteroids Three-month follow-up EC-MPS Tacrolimus Corticosteroid One-year follow-up

Population 145 adult patients (Brazil) 80 adult patients (Japan) 145 adult patients (Brazil) 284 pediatric and young adult patients (USA) 189 adult patients (France) 148 adult patients (Brazil) 97 adult patients (Brazil)

Table 1. Genes related to mycophenolic acid metabolism in kidney transplantation

Study design Retrospective (Case- control) Prospective Retrospective (Case- control) Retrospective (Case- Control), multicenter Prospective, multicenter (Dominos study) Prospective, multicenter Prospective

Allele frequency 356T: 46% - 8721T: 22% - rs11572076A: 0.5% CYP2C8*3: 9% c.416A: 9% c.1196G:10%

rs62028647 (356C>T) rs3890213 (-1548A>G) rs2303218 (4595A>G) rs2241409 (8721C>T) rs11572076 G>A CYP2C8*3 + rs10509681 (c.1196A>G)]

Variant [rs11572080 (c.416G>A)

Gene CES1 CES2 CYP2C8