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Nguyen et al. J Transl Genet Genom 2018;2:19 I http://dx.doi.org/10.20517/jtgg.2018.20 Page 9 of 11

Figure 4. Correlation between inhibition coefficients and ΔSUV max . For a drug or a drug combination, the inhibition coefficient is calculated
as (a’-a)/a. The Kendall rank correlation coefficient is calculated between a given patient ΔSUV max for one chemotherapy regimen and
the inhibition coefficient for the same regimen in his corresponding TNBC xenograft. There is a significant correlation between these two
2
parameters (R = 0.7, P < 0.05). TNBC: triple negative breast cancer; SUV: standard uptake value

engraftment rate. However, for metastatic TNBCs, the engraftment probability of metastatic samples is high,
up to 80% . Individual PDXs could thus be useful in co-clinical trials, using individual xenografts for the
[30]
development of new therapeutic agents in patients with cancer resistant to standard treatments [13,31,32] .

The combination of gene expression profiling and individual PDXs is a promising method, and could be
proposed as a personalized therapeutic resort for women with metastatic TNBCs.

DECLARATIONS
Acknowledgments
We would like to thank Mrs. A. Swaine for revising the English language.

Authors’ contributions
Collected and assembled the data: Nguyen TT, Bousquet G
Provided data analysis and interpretation: Nguyen TT, El Bouchtaoui M, Janin A, Bousquet G
Drafted the manuscript: Nguyen TT, Janin A, Bousquet G
Analyzed the transcriptomic data: Feugeas JP
Provided the analysis of PET/CT data: Vercillino L
Performed imaging-guided tumor biopsies: de Bazelaire C
Located financial support and provided administrative support: Janin A
Conceived and designed the study, provided the study material or patients: Bousquet G
Read and approved the final manuscript: Nguyen TT, El Bouchtaoui M, Feugeas JP, Vercillino L, de Bazelaire C,
Janin A, Bousquet G