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Page 6 of 11 Zhang et al. J Transl Genet Genom 2018;2:18. I https://doi.org/10.20517/jtgg.2018.22

A miR-98 B miR-126

28

Log 20 26
Log
cop
cop 24
y 15
y
nu 22
10 nu
20

CL1 CL2 CL3 CL4 CL1 CL2 CL3 CL4
C D
Blood eosinophil per cluster miR-570-3p

1500 Log 20
Eosinophils (cells/ml) 1000 cop 15

y
500
nu
10
0 5
CL1 CL2 CL3 CL4 CL1 CL2 CL3 CL4
Group 4 Group 5

miR-148a miR-365
E F

24
22
Log Log 20
cop 20 cop
15
y 18 y
nu nu
16 10
14

CL1 CL2 CL3 CL4 CL1 CL2 CL3 CL4
Figure 2. Representative miRNA expression patterns in each group. Box and whisker plots of representative miRNAs in each of the five
groups identified (panels A, B, D-F), and blood eosinophil levels (panel C). CL: cluster

Asthma severity and asthma control
Cluster 1 was comprised of mostly mild asthmatics (9/10 mild), while Cluster 3 and 4 were mostly severe
asthma (18/20 and 9/13, respectively). Asthma severity in Cluster 2 was variable, and included 5 mild, 8
moderate, and 7 severe persistent asthmatics. Asthma control differed across the clusters. Cluster 1 had the
best control (mean ACT of 21.2) followed by Cluster 2 (mean ACT of 17.7), Cluster 3 (mean ACT of 13.7), and