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Page 8 of 15 Przanowski et al. J Transl Genet Genom 2018;2:2 I http://dx.doi.org/10.20517/jtgg.2017.03

Table 1. List of XCIFs identified to-date using genetic, biochemical and proteomics screens [32-34,40-43,47-49]
Function XCIF Pharmalogical inhibitors Surface Study Chromosome
tested (names)/availability protein mouse (human)
(+/-)
53BP1 - - [40] 2 (15)
ANAPC5 - - [40] 5 (12)
AURKA VX680, MLN8237/+ - [32-34] 2 (20)
AURKB VX680, MLN8237/+ - [33,49] 11 (17)
BRCA2 - - [34] 5 (13)
CDC25a - - [40] 9 (3)
CDK4 + - [40] 10 (12)
CLASPIN - - [34] 4 (1)
GINS3 - - [34] 8 (16)
Cell cycle regulation LRWD1 - - [40] 5 (7)
MCM8 - - [34] 2 (20)
NF1 - - [32] 11 (17)
ORC2 - - [40] 1 (2)
PARP6 + - [34] 9 (15)
PLK2 + - [34] 13 (5)
RAD21 + - [34,49] 15 (8)
SKP2 + - [40] 15 (5)
SYCP1 - - [40] 3 (1)
ZWINT - - [40] 10 (10)
BCAS2 - - [40] 3 (1)
LBR - - [49] 1 (1)
METTL3 + - [40] 14 (14)
PTBP1 - - [40] 10 (19)
RBM15 - - [42] 3 (1)
RNA binding and procesing
RRM2 HU, Resveratrol/+ - [41] 12 (2)
SSB - - [40] 2 (2)
WTAP - - [42] 17 (6)
HNRNPK - - [42,47] 13 (9)
HNRNPU - - [42,47,49] 17 (1)
CCND2 + - [40] 6 (12)
ERBB4 + - [34] 1 (2)
PDPK1 OSU-04402, BX912/+ - [32,34] 17 (16)
PIK3CB LY294002; GNE-407 - [32,34] 9 (3)
Signaling kinases
PRKD3 + - [34] 17 (2)
PRPF4B + - [40] 13 (6)
SGK2 + - [34] 2 (20)
SRPK2 + - [40] 5 (7)
ACVR1 + + [32,34] 2 (2)
ACVR1b + + [34] 15 (12)
Bmpr2 + + [34] 1 (2)
PRRX1 - - [40] 1 (1)
TGF-B/BMP signaling
RNF165 - - [32] 18 (18)
SMAD2 - - [34] 18 (18)
SNIP1 - - [34] 4 (1)
ZFYVE9 - - [34] 4 (1)
ATF7IP - [41] 6 (12)
ARID4B - - [34] 13 (1)
CTCF - - [49] 8 (16)
DNMT1 5-Azacytidine/+ - Multiple studies 9 (19)
DTX3L - - [34] 16 (3)
H2AFX - - [40] 9 (11)
HMGN3 - - [40] 9 (6)
ID3 - - [40] 4 (1)
KLF17 - - [40] 4 (1)
MBD1 - - [40] 18 (18)
MSL2L1 - - [34] 9 (3)