Page 444 - Read Online

Safa. J Cancer Metastasis Treat 2020;6:36 I http://dx.doi.org/10.20517/2394-4722.2020.55 Page 11 of 15

24. Chatterjee R, Chatterjee J. ROS and oncogenesis with special reference to EMT and stemness. Eur J Cell Biol 2020;99:151073.
25. Garg M. Epithelial plasticity, autophagy and metastasis: potential modifiers of the crosstalk to overcome therapeutic resistance. Stem Cell
Rev Rep 2020;16:503-10.
26. Valle S, Martin-Hijano L, Alcalá S, Alonso-Nocelo M, Sainz B Jr. The ever-evolving concept of the cancer stem cell in pancreatic cancer.
Cancers (Basel) 2018;10:33.
27. Begum A, Ewachiw T, Jung C, Huang A, Norberg KJ, et al. The extracellular matrix and focal adhesion kinase signaling regulate cancer
stem cell function in pancreatic ductal adenocarcinoma. PLoS One 2017;12:e0180181.
28. Zhu H, Wang D, Liu Y, Su Z, Zhang L, et al. Role of the hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-
stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells. Cancer Cell Int 2013;13:119.
29. Santamaria-Martinez A. Huelsken J. The niche under siege: Novel targets for metastasis therapy. J Intern Med 2013;274:127136.
30. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J. Identification of human brain tumour initiating cells. Nature 2004;432:396-401.
31. Ginestier C, Hur MH, Charafe-Jau EC, Monville F, Dutcher J. et al. ALDH1 is a marker of normal and malignant human mammary stem
cells and a predictor of poor clinical outcome. Cell Stem Cell 2007;1:555-67.
32. Balic A, Dorado J, Alonso-Gómez M, Heeschen C. Stem cells as the root of pancreatic ductal adenocarcinoma. Exp Cell Res
2012;318:691-4.
33. Van den Hoogen C, van der Horst G, Cheung H, Buijs JT, Lippitt JM, et al. High aldehyde dehydrogenase activity identifies tumor-
initiating and metastasis-initiating cells in human prostate cancer. Cancer Res 2010;70:5163-73.
34. O’Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice.
Nature 2007;445:106-10.
35. Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer
2008;8:755-68.
36. Malta TM, Sokolov A, Gentles AJ, Burzykowski T, Poisson L, et al. Machine learning identifies stemness features associated with
oncogenic dedifferentiation. Cell 2018;173:338-54.e15.
37. Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary
glioblastoma. Science 2014;344:1396-401.
38. Wilson MM, Weinberg RA, Lees JA, Guen VJ. Emerging mechanisms by which EMT programs control stemness. Trends Cancer
2020;6:775-80.
39. Castellanos JA, Merchant NB, Nagathihalli NS. Emerging targets in pancreatic cancer: epithelial-mesenchymal transition and cancer stem
cells. Onco Targets Ther 2013;6:1261-7.
40 Zhou P, Li B, Liu F, Zhang M, Wang Q, et al. The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for
treatment resistance in pancreatic cancer. Mol Cancer 2017;16:52.
41. Rodriguez-Aznar E, Wiesmüller L, Sainz B Jr, Hermann PC. EMT and stemness-Key players in pancreatic cancer stem cells. Cancers
(Basel) 2019;11:1136.
42. Brabletz T. To differentiate or not-Routes towards metastasis. Nat Rev Cancer 2012;12:425-36.
43. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, et al. The epithelial-mesenchymal transition generates cells with properties of stem
cells. Cell 2008;133:704-15.
44. Pattabiraman DR. Weinberg RA. Tackling the cancer stem cells-What challenges do they pose? Nat Rev Drug Discov 2014;13:497-12.
45. Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, et al. EMT and dissemination precede pancreatic tumor formation. Cell
2012;148:349-61.
46. Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem
cell states in the breast. Cell 2011;145:926-40.
47. Ball CR, Oppel F, Ehrenberg KR, Dubash TD, Dieter M, et al. Succession of transiently active tumor-initiating cell clones in human
pancreatic cancer xenografts. EMBO Mol Med 2017;9:918-32.
48. Batlle E, Clevers H. Cancer stem cells revisited. Nat Med 2017;23:1124-34.
49. Yang G, Quan Y, Wang W, Fu Q, Wu J, et al. Dynamic equilibrium between cancer stem cells and non-stem cancer cells in human SW620
and MCF-7 cancer cell populations. Br J Cancer 2012;106:1512-9.
50. Dalla Pozza E, Dando I, Biondani G, Brandi J, Costanzo C, et al, Pancreatic ductal adenocarcinoma cell lines display a plastic ability to bi
directionally convert into cancer stem cells. Int J Oncol 2015;46:1099-108.
51. Erez, N, Truitt M, Olson P, Arron ST, Hanahan D. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-
promoting inflammation in an NF-κB-dependent manner. Cancer Cell 2010;17:135-47.
52. Bazzichetto C, Conciatori F, Falcone I, Cognetti F, Milella M, et al. Advances in tumor-stroma interactions: Emerging role of cytokine
network in colorectal and pancreatic cancer. J Oncol 2019;2019:5373580.
53. Geismann C, Schäfer H, Gundlach JP, Hauser C, Egberts JH, et al. NF-κB dependent chemokine signaling in pancreatic cancer. Cancers
(Basel) 2019;11:1445.
54. Knapinska AM, Estrada CA, Fields GB. The roles of matrix metalloproteinases in pancreatic cancer. Prog Mol Biol Transl Sci
2017;148:339-54.
55. Mutgan AC, Besikcioglu HE, Wang S, Friess H, Ceyhan GO, et al. Insulin/IGF-driven cancer cell-stroma crosstalk as a novel therapeutic
target in pancreatic cancer. Mol Cancer 2018;17:66.
56. Lee NH, Nikfarjam M, He H. Functions of the CXC ligand family in the pancreatic tumor microenvironment. Pancreatology
2018;18:705-16.