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Finzel et al. J Cancer Metastasis Treat 2018;4:21  I  http://dx.doi.org/10.20517/2394-4722.2018.10                             Page 9 of 10

               which cannot be achieved by performing only one type of biopsy, and that the inclusion of ctDNA profiling
               should be considered in routine oncology care especially for cancers where targeted therapies are approved
               or in development.



               DECLARATIONS
               Acknowledgments
               We thank all the clinicians and patients who provided the biopsy samples used in the study.


               Authors’ contributions
               Conceived and designed the study: Laes JF
               Worked on the acquisition of data, the writing of the article and the analysis and interpretation of data: all
               authors
               Reviewed and agreed on the manuscript before submission: all authors


               Data source and availability
               Due to privacy reasons, the data of this study cannot be open for readers. Nonetheless, if a researcher asks
               for data, they could be shared upon the signature of a confidentiality agreement.

               Financial support and sponsorship
               This study was sponsored by OncoDNA SA. The costs associated with the development and publishing of the
               manuscript were provided by OncoDNA SA.

               Conflicts of interest
               All authors are employees of OncoDNA. Ghitti G and Laes JF report ownership of OncoDNA shares.


               Patient consent
               Patients gave informed consent for their tumor analysis data to be published.

               Ethics approval
               This study is not approved by IRB; however, all patients signed an informed consent before their samples
               underwent molecular profiling according to Belgian law.


               Copyright
               © The Author(s) 2018.



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