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Corona et al. Adenosine A2B receptor in cancer

Accumulating knowledge of the adenosine signalling murine microglia through p38 MAPK kinase pathway. Pharmacol
targets drives the identification of biomarkers and Res 2017;117:9-19.
predictors of response/resistance, opening therefore 9. Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y,
the possibility of a personalised therapeutic approach. Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov
I, Dikov MM. Adenosine receptors in regulation of dendritic cell
differentiation and function. Blood 2008;112:1822-31.
DECLARATIONS 10. Whiteside TL. Targeting adenosine in cancer immunotherapy:
a review of recent progress. Expert Rev Anticancer Ther
Authors’ contributions 2017;17:527-35.
Concept and design of the article: S.P. Corona, N. 11. Mittal D, Young A, Stannard K, Yong M, Teng MW, Allard B,
Sobhani, D. Generali Stagg J, Smyth MJ. Antimetastatic effects of blocking PD-1 and the
adenosine A2A receptor. Cancer Res 2014;74:3652-8.
Definition of intellectual content, literature search and 12. Allard B, Pommey S, Smyth MJ, Stagg J. TTargeting CD73 enhances
manuscript preparation: S.P. Corona the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs. Clin
Manuscript editing: S.P. Corona, D. Generali Cancer Res 2013;19:5626-35.
13. Iannone R, Miele L, Maiolino P, Pinto A, Morello S. Adenosine
Financial support and sponsorship limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse
None. melanoma model. Am J Cancer Res 2014;4:172-81.
14. Beavis PA, Milenkovski N, Henderson MA, John LB, Allard B,
Conflicts of interest Loi S, Kershaw MH, Stagg J, Darcy PK. Adenosine receptor 2A
There are no conflicts of interest. blockade increases the efficacy of Anti-PD-1 through enhanced
antitumor T-cell responses. Cancer Immunol Res 2015;3:506-17.
Patient consent 15. Ma DF, Kondo T, Nakazawa T, Niu DF, Mochizuki K, Kawasaki
T, Yamane T, Katoh R. Hypoxia-inducible adenosine A2B receptor
Not applicable. modulates proliferation of colon carcinoma cells. Hum Pathol
2010;41:1550-7.
Ethics approval 16. Desmet CJ, Gallenne T, Prieur A, Reyal F, Visser NL, Wittner BS,
Not applicable. Smit MA, Geiger TR, Laoukili J, Iskit S, Rodenko B, Zwart W, Evers
B, Horlings H, Ajouaou A, Zevenhoven J, van Vliet M, Ramaswamy
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208 Journal of Cancer Metastasis and Treatment ¦ Volume 3 ¦ September 27, 2017