Page 113 - Read Online

Youbi et al. J Cancer Metastasis Treat 2017;3:105-10 Journal of
DOI: 10.20517/2394-4722.2017.07
Cancer Metastasis and Treatment

www.jcmtjournal.com
Short Communication Open Access

Management of choroidal metastasis using

external beam radiotherapy: a retrospective

study and review of the literature

Zakaria Ahmed Youbi, Enachescu Ciprian, Caraivan Ionela, Bennani Zineb, Khounigere Majdouline, Kotzki Léa,
Pialat Pierre-Marie, Sesques Pierre, Yossi Séna
Department of Radiation Therapy, South Lyon Hospital, 69495 Lyon, France.

Correspondence to: Dr. Zakaria Ahmed Youbi, Department of Radiation Therapy, South Lyon Hospital, 165 Chemin du Grand Revoyet, Pierre
Benite, 69495 Lyon, France. E-mail: zakaria.youbi@gmail.com

How to cite this article: Youbi ZA, Ciprian E, Ionela C, Zineb B, Majdouline K, Léa K, Pierre-Marie P, Pierre S, Séna Y. Management of choroidal
metastasis using external beam radiotherapy: a retrospective study and review of the literature. J Cancer Metastasis Treat 2017;3:105-10.
ABSTRACT
Article history: Aim: Choroidal metastases are rare in the evolution of solid cancers and constitute
Received: 11-01-2017 exceptional metastatic sites involving functional visual prognosis. The authors conducted
Accepted: 23-03-2017 a retrospective study to determine the interest of external radiotherapy for the treatment
Published: 30-06-2017 of choroidal metastases. Methods: The authors reviewed the records of 28 patients with
choroidal metastases who had breast (n = 15), lung (n = 9), ovarian (n = 1), kidney (n =
Key words: 1), prostate (n = 1) cancer or carcinoma with unknown primitive at the moment of the
Radiotherapy, diagnosis (n = 1). The median age was 58 years (extremes: 34-71 years). Tumor stage before
choroid, the discovery of metastatic choroidal metastasis was 50% of patients. Ocular involvement
metastasis, was unilateral (n = 22) or bilateral (n = 6). The delivered doses ranged from 20 to 50
ocular, Gy fractionated with 3-5 Gy in 2D technique (n = 5), conformational (n = 21), intensity
tumors, modulation (n = 2). The most widely used prescription scheme delivered 30 Gy in 10
visual, fractions (64%) using two 6 MV photons beams. Results: At the end of irradiation, 13
acuity patients (46%) showed an improvement of eye symptoms. For the others, a stabilization in
symptoms was noted (n = 15). No patient had visual degradation. No acute or late grade 2-3
toxicities were objectified. The histological type did not influence the response (P = 0.5).
There was no dose relationship-response in our series. Conclusion: External radiation
therapy is a useful technique in the palliative treatment of choroidal metastases. Acute and
late toxicities are acceptable.

INTRODUCTION of the patient in the short to medium term. In
several autopsy series, they have an incidence of
Choroidal metastases are rare in the development 4% to 12% in patients with solid tumors. [1,2] The
of solid cancers that can affect the visual prognosis uveal tract is the most common site of intraocular

Quick Response Code:
This is an open access article distributed under the terms of the Creative Commons Attribution-
NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work
non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

For reprints contact: service@oaepublish.com

© 2017 OAE Publishing Inc. www.oaepublish.com 105