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Poddar et al. J Cancer Metastasis Treat 2016;2:443-5 Journal of
DOI: 10.20517/2394-4722.2016.36
Cancer Metastasis and Treatment

www.jcmtjournal.com
Case Report Open Access

Squamous cell carcinoma of tongue 18 years

after renal transplantation: a case report

Jyoti Poddar, Ashutosh Das Sharma, Ubrangala Suryanarayana Kunikullaya

Department of Radiotherapy, the Gujarat Cancer and Research Institute, Asarwa, Ahmedabad 380016, India.
Correspondence to: Dr. Jyoti Poddar, Department of Radiotherapy, the Gujarat Cancer and Research Institute, Asarwa, Ahmedabad 380016, India.
E-mail: poddarjyo@gmail.com
How to cite this article: Poddar J, Sharma AD, Kunikullaya US. Squamous cell carcinoma of tongue 18 years after renal transplantation: a case
report. J Cancer Metastasis Treat 2016;2:443-5.
ABSTRACT
Article history: Solid organ transplant recipients are at increased risk of developing malignancies, even
Received: 19-06-2016 decades after transplant, due to the prolonged use of immunosuppressant drugs. A 35-year-old
Accepted: 10-11-2016 male underwent renal transplant for end stage renal disease 18 years previously and was
Published: 25-11-2016 on immunosuppressive drugs since that time and was on regular follow up. In 2016, he
developed a squamous cell carcinoma of tongue, which was operated and adjuvant radiation
Key words: therapy was given. The patient is currently on follow up and asymptomatic. Though
Renal transplant, squamous cell carcinoma of tongue is a relatively common malignancy in the general
immunosuppression, population, it is very rare in transplant recipients. Hence, such patients require longer
carcinoma tongue follow-up, active surveillance, and screening for early diagnosis and prompt treatment of
premalignant and malignant conditions.

INTRODUCTION involving the tongue are an uncommon occurrence
in this context, whereas it is a common intra-oral
Renal transplant, which is usually the treatment of malignancy in the general population. We report such
[3]
choice for end stage renal failure, predisposes the an unusual case occurring eighteen years after renal
recipient to an increased risk of developing malignancies transplantation.
and this risk increases with increasing duration of
[1]
immunosuppression. This risk is largely attributable The purpose is to draw attention towards the need
to the immunosuppressive drugs used to combat graft of extended follow up and active surveillance to look
rejection (with an incidence of up to approximately 5% for malignancies in unusual locations and for early
to 6%). The malignancies commonly encountered are diagnosis and better management.
skin cancers and those of the lymphatic system. Of
[2]
these, squamous cell carcinomas make up the bulk of CASE REPORT
epithelial carcinomas, involving most commonly skin,
lips, cervix, and, rarely, lung. However, malignancies A 5-year-old child (1985) developed off and on reeling

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