Page 29 - Read Online
P. 29
Cross-talk between notch and the estrogen receptor in breast cancer Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating
suggests novel therapeutic approaches. Cancer Res 2008;68:5226-35. mutations of NOTCH1 in human T cell acute lymphoblastic
19. Osipo C, Patel P, Rizzo P, Clementz AG, Hao L, Golde TE, Miele leukemia. Science 2004;306:269-71.
L. ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer 39. Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A,
cells to a gamma-secretase inhibitor. Oncogene 2008;27:5019-32. Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe
20. Benedito R, Rocha SF, Woeste M, Zamykal M, Radtke F, Casanovas MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster JC. c-Myc
O, Duarte A, Pytowski B, Adams RH. Notch-dependent VEGFR3 is an important direct target of Notch1 in T-cell acute lymphoblastic
upregulation allows angiogenesis without VEGF-VEGFR2 signalling. leukemia/lymphoma. Genes Dev 2006;20:2096-109.
Nature 2012;484:110-4. 40. Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M,
21. Caliceti C, Nigro P, Rizzo P, Ferrari R. ROS, Notch, and Wnt Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal
signaling pathways: crosstalk between three major regulators of AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons
cardiovascular biology. Biomed Res Int 2014;2014:318714. R, Zuniga-Pflucker JC, Dominguez M, Ferrando AA. Mutational
22. Romero-Carvajal A, Navajas Acedo J, Jiang L, Kozlovskaja- loss of PTEN induces resistance to NOTCH1 inhibition in T-cell
Gumbriene A, Alexander R, Li H, Piotrowski T. Regeneration of leukemia. Nat Med 2007;13:1203-10.
sensory hair cells requires localized interactions between the Notch 41. Witkowski MT, Cimmino L, Hu Y, Trimarchi T, Tagoh H, McKenzie
and Wnt pathways. Dev Cell 2015;34:267-82. MD, Best SA, Tuohey L, Willson TA, Nutt SL, Busslinger M,
23. Xie G, Karaca G, Swiderska-Syn M, Michelotti GA, Kruger L, Chen Aifantis I, Smyth GK, Dickins RA. Activated Notch counteracts
Y, Premont RT, Choi SS, Diehl AM. Cross-talk between Notch and Ikaros tumor suppression in mouse and human T-cell acute
Hedgehog regulates hepatic stellate cell fate in mice. Hepatology lymphoblastic leukemia. Leukemia 2015;29:1301-11.
2013;58:1801-13. 42. Gallahan D, Jhappan C, Robinson G, Hennighausen L, Sharp R,
24. Guruharsha KG, Kankel MW, Artavanis-Tsakonas S. The Notch Kordon E, Callahan R, Merlino G, Smith GH. Expression of a
signalling system: recent insights into the complexity of a conserved truncated Int3 gene in developing secretory mammary epithelium
pathway. Nat Rev Genet 2012;13:654-66. specifically retards lobular differentiation resulting in tumorigenesis.
25. de la Pompa JL, Epstein JA. Coordinating tissue interactions: Cancer Res 1996;56:1775-85.
notch signaling in cardiac development and disease. Dev Cell 43. Hu C, Dievart A, Lupien M, Calvo E, Tremblay G, Jolicoeur P.
2012;22:244-54. Overexpression of activated murine Notch1 and Notch3 in transgenic
26. Gridley T. Notch signaling in the vasculature. Notch Signal mice blocks mammary gland development and induces mammary
2010;92:277-309. tumors. Am J Pathol 2006;168:973-90.
27. Gude N, Joyo E, Toko H, Quijada P, Villanueva M, Hariharan N, Sacchi 44. Li ZL, Chen C, Yang Y, Wang C, Yang T, Yang X, Liu SC. Gamma
V, Truffa S, Joyo A, Voelkers M, Alvarez R, Sussman MA. Notch secretase inhibitor enhances sensitivity to doxorubicin in MDA-
activation enhances lineage commitment and protective signaling in MB-231 cells. Int J Clin Exp Pathol 2015;8:4378-87.
cardiac progenitor cells. Basic Res Cardiol 2015;110:29. 45. Yao K, Rizzo P, Rajan P, Albain K, Rychlik K, Shah S, Miele L.
28. Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo Notch-1 and notch-4 receptors as prognostic markers in breast
T, Hrabe de Angelis M, Lendahl U, Edlund H. Notch signalling cancer. Int J Surg Pathol 2011;19:607-13.
controls pancreatic cell differentiation. Nature 1999;400:877-81. 46. Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer SM, Zlobin A,
29. Lanford PJ, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley Osborne BA, Gottipati S, Aster JC, Hahn WC, Rudolf M, Siziopikou
T, Kelley MW. Notch signalling pathway mediates hair cell K, Kast WM, Miele L. Activation of Notch-1 signaling maintains
development in mammalian cochlea. Nat Genet 1999;21:289-92. the neoplastic phenotype in human Ras-transformed cells. Nat Med
30. van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs 2002;8:979-86.
M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, 47. Wang K, Zhang Q, Li D, Ching K, Zhang C, Zheng X, Ozeck
Clevers H. Notch/gamma-secretase inhibition turns proliferative M, Shi S, Li X, Wang H, Rejto P, Christensen J, Olson P. PEST
cells in intestinal crypts and adenomas into goblet cells. Nature domain mutations in Notch receptors comprise an oncogenic driver
2005;435:959-63. segment in triple-negative breast cancer sensitive to a gamma-
31. Gridley T. Notch signaling and inherited disease syndromes. Hum secretase inhibitor. Clin Cancer Res 2015;21:1487-96.
Mol Genet 2003;12:R9-13. 48. Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready
32. High FA, Epstein JA. The multifaceted role of Notch in cardiac DR, Lockwood G, Egan SE. High-level coexpression of JAG1 and
development and disease. Nat Rev Genet 2008;9:49-61. NOTCH1 is observed in human breast cancer and is associated
33. Radtke F, Fasnacht N, Macdonald HR. Notch signaling in the with poor overall survival. Cancer Res 2005;65:8530-7.
immune system. Immunity 2010;32:14-27. 49. Parr C, Watkins G, Jiang WG. The possible correlation of Notch-1
34. Ito T, Allen RM, Carson WF, Schaller M, Cavassani KA, Hogaboam and Notch-2 with clinical outcome and tumour clinicopathological
CM, Lukacs NW, Matsukawa A, Kunkel SL. The critical role of parameters in human breast cancer. Int J Mol Med 2004;14:779-86.
Notch ligand Delta-like 1 in the pathogenesis of influenza A virus 50. O’Neill CF, Urs S, Cinelli C, Lincoln A, Nadeau RJ, Leon R, Toher
(H1N1) infection. PLoS Pathog 2011;7:e1002341. J, Mouta-Bellum C, Friesel RE, Liaw L. Notch2 signaling induces
35. Li Y, Wu S, Pu J, Huang X, Zhang P. Dengue virus up-regulates apoptosis and inhibits human MDA-MB-231xenograft growth. Am
expression of notch ligands Dll1 and Dll4 through interferon-beta J Pathol 2007;171:1023-36.
signalling pathway. Immunology 2015;144:127-38. 51. Harrison H, Farnie G, Howell SJ, Rock RE, Stylianou S, Brennan KR,
36. Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Bundred NJ, Clarke RB. Regulation of breast cancer stem cell activity
Sklar J. TAN-1, the human homolog of the Drosophila notch by signaling through the Notch4 receptor. Cancer Res 2010;70:709-18.
gene, is broken by chromosomal translocations in T lymphoblastic 52. Selever J, Gu G, Lewis MT, Beyer A, Herynk MH, Covington KR,
neoplasms. Cell 1991;66:649-61. Tsimelzon A, Dontu G, Provost P, Di Pietro A, Boumendjel A, Albain
37. Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J, K, Miele L, Weiss H, Barone I, Ando S, Fuqua SA. Dicer-mediated
Baltimore D. Exclusive development of T cell neoplasms in mice upregulation of BCRP confers tamoxifen resistance in human breast
transplanted with bone marrow expressing activated Notch alleles. cancer cells. Clin Cancer Res 2011;17:6510-21.
J Exp Med 1996;183:2283-91. 53. Yun J, Pannuti A, Espinoza I, Zhu H, Hicks C, Zhu X, Caskey
38. Weng AP, Ferrando AA, Lee W, Morris JPt, Silverman LB, M, Rizzo P, D’Souza G, Backus K, Denning MF, Coon J, Sun M,
Journal of Cancer Metastasis and Treatment ¦ Volume 2 ¦ Issue 1 ¦ January 15, 2016 ¦ 19