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Case Report

Metastatic high-grade neuroendocrine tumor of mandible

Jitender Batra , Chinmay D. Vakade , Sonal Grover , Gyanander Attresh 1
2
2
1
1 Department of Oral and Maxillofacial Surgery, Post Graduate Institute of Dental Sciences, Pt. B.D. Sharma UHS, Rohtak 124001, Haryana, India.
2 Department of Oral and Maxillofacial Surgery, Bapuji Dental College and Hospital, Davangere 577004, Karnataka, India.
Correspondence to: Dr. Jitender Batra, Department of Oral and Maxillofacial Surgery, Post Graduate Institute of Dental Sciences, Pt. B.D. Sharma
UHS, Rohtak 124001, Haryana, India. E-mail: dr.batrajatin@gmail.com

A B S T R AC T
Neuroendocrine tumors of the oral cavity and jaws are exceedingly rare. They include paragangliomas, a melanotic neuroectodermal
tumor of infants, small cell carcinomas, and Merckel cell carcinomas. Most have been non-functional in nature. Breast, lung, liver,
colon, and prostate are the most common reported primary malignancies which can metastasize to the oral cavity. In most cases,
oral metastases involve maxilla and mandible rather than soft tissues. The premolar-molar region is the most common localization.
The purpose of this article is to describe a rare case of a high grade neuroendocrine tumor of the mandible which metastasized
from the cervix.
Key words: Large/small cell carcinoma of mandible; metastatic tumor/carcinoma to the mandible; neuroendocrine/carcinoid
tumor of mandible

INTRODUCTION CASE REPORT

Metastatic lesions to the jaws are known to simulate A 35-year-old female patient reported with the chief
periodontal and pulpal disease and other radiolucent lesions complaint of a swelling in the right lower back region of
that can occur in the jaws. Breast, lung, liver, colon, and the jaw for 20 days. Her history revealed a painful tooth in
prostate cancers are the most commonly reported primary the region which was extracted 1 month earlier, followed by
malignancies which can metastasize to the oral cavity. [1] the appearance of swelling few days later. The swelling was
initially small in size to start with but gradually progressed
Tumors of the neuroendocrine system constitute a to the present size and was associated with loss of sensation
heterogeneous group of lesions that vary in origin, location, on the right side of the lower lip. Medical history revealed
histological appearance, the degree of differentiation, that the patient had undergone a hysterectomy for small
biologic behavior, functional activity and size but cell carcinoma of cervix 11 months earlier.
share certain histochemical, immunohistochemical, and
ultrastructural characteristics. [2] Extra-oral examination revealed a solitary swelling in the
right lower third of the face measuring around 2.5 cm ×
Neuroendocrine tumors comprise carcinoids, islet cell 2 cm in the greatest dimensions, roughly oval in shape with
tumors, medullary carcinomas of the thyroid, mastocytomas, diffuse borders. Right sub-mandibular lymph nodes were
melanomas, Merkel cell tumors of the skin, neurocytomas, palpable, tender, firm-to-hard inconsistency, and fixed.
oat cell carcinomas, paragangliomas, pinealomas, and Intraoral examination revealed the presence of solitary
pituitary adenomas. [3]
swelling in the right mandibular molar region, measuring
1.5 cm × 1 cm. Vestibular obliteration was evident [Figure
The purpose of this article is to describe a rare case of a
high-grade neuroendocrine tumor of the mandible which 1]. Clinically, teeth number 26, 36, 46, 47 and 48 were
metastasized from the cervix.
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How to cite this article: Batra J, Vakade CD, Grover S, Attresh G.
Metastatic high-grade neuroendocrine tumor of mandible. J Cancer
DOI: Metastasis Treat 2016;2:127-9.
10.4103/2394-4722.170022
Received: 07-05-2015; Accepted: 29-10-2015.

©2016 Journal of Cancer Metastasis and Treatment ¦ Published by OAE Publishing Inc. 127