Page 73 - Read Online
P. 73
Fockens P, Buttar NS, Krishnadath KK. A pSMAD/CDX2 Morris D, Nwokolo C, Isaacs P, Rodgers C, Ragunath K,
complex is essential for the intestinalization of epithelial MacDonald C, Haigh C, Monk D, Davies G, Wajed S,
metaplasia. Cell Rep 2014;7:1197-210. Johnston D, Gibbons M, Cullen S, Church N, Langley R,
26. Wang DH, Clemons NJ, Miyashita T, Dupuy AJ, Zhang W, Griffi n M, Alderson D, Deloukas P, Hunt SE, Gray E,
Szczepny A, Corcoran-Schwartz IM, Wilburn DL, Dronov S, Potter SC, Tashakkori-Ghanbaria A, Anderson M,
Montgomery EA, Wang JS, Jenkins NA, Copeland NA, Brooks C, Blackwell JM, Bramon E, Brown MA, Casas JP,
Harmon JW, Phillips WA, Watkins DN. Aberrant Corvin A, Duncanson A, Markus HS, Mathew CG,
epithelial-mesenchymal hedgehog signaling characterizes Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC,
Barrett’s metaplasia. Gastroenterology 2010;138:1810-22. Viswanathan AC, Wood N, Trynka G, Wijmenga C, Cazier JB,
27. Zhang X, Westerhoff M, Hart J. Expression of SOX9 and Atherfold P, Nicholson AM, Gellatly NL, Glancy D,
CDX2 in nongoblet columnar-lined esophagus predicts the Cooper SC, Cunningham D, Lind T, Hapeshi J, Ferry D,
detection of Barrett’s esophagus during follow-up. Mod Pathol Rathbone B, Brown J, Love S, Attwood S, MacGregor S,
2015;28:654-61. Watson P, Sanders S, Ek W, Harrison RF, Moayyedi P, de
28. Van Dop WA, Rosekrans SL, Uhmann A, Jaks V, Caestecker J, Barr H, Stupka E, Vaughan TL, Peltonen L,
Offerhaus GJ, van den Bergh Weerman MA, Kasper M, Spencer CC, Tomlinson I, Donnelly P, Jankowski JA,
Heijmans J, Hardwick JC, Verspaget HW, Hommes DW, Esophageal Adenocarcinoma Genetics C, Wellcome Trust
Toftgard R, Hahn H, van den Brink GR. Hedgehog signalling Case Control C. Common variants at the MHC locus and at
stimulates precursor cell accumulation and impairs epithelial chromosome 16q24.1 predispose to Barrett’s esophagus. Nat
maturation in the murine oesophagus. Gut 2013;62:348-57. Genet 2012;44:1131-6.
29. Clemons NJ, Wang DH, Croagh D, Tikoo A, Fennell CM, 33. Martin V, Shaw-Smith C. Review of genetic factors in
Murone C, Scott AM, Watkins DN, Phillips WA. Sox9 drives intestinal malrotation. Pediatr Surg Int 2010;26:769-81.
columnar differentiation of esophageal squamous epithelium: a 34. Levine DM, Ek WE, Zhang R, Liu X, Onstad L, Sather C,
possible role in the pathogenesis of Barrett’s esophagus. Am J Lao-Sirieix P, Gammon MD, Corley DA, Shaheen NJ,
Physiol Gastrointest Liver Physiol 2012;303:G1335-46. Bird NC, Hardie LJ, Murray LJ, Reid BJ, Chow WH,
30. Quante M, Bhagat G, Abrams JA, Marache F, Good P, Risch HA, Nyren O, Ye W, Liu G, Romero Y, Bernstein L,
Lee MD, Lee Y, Friedman R, Asfaha S, Dubeykovskaya Z, Wu AH, Casson AG, Chanock SJ, Harrington P, Caldas I,
Mahmood U, Figueiredo JL, Kitajewski J, Shawber C, Debiram-Beecham I, Caldas C, Hayward NK, Pharoah PD,
Lightdale CJ, Rustgi AK, Wang TC. Bile acid and Fitzgerald RC, Macgregor S, Whiteman DC, Vaughan TL.
infl ammation activate gastric cardia stem cells in a mouse A genome-wide association study identifi es new susceptibility
model of Barrett-like metaplasia. Cancer Cell 2012;21:36-51. loci for esophageal adenocarcinoma and Barrett’s esophagus.
31. Palles C, Chegwidden L, Li X, Findlay JM, Farnham G, Nat Genet 2013;45:1487-93.
Castro Giner F, Peppelenbosch MP, Kovac M, Adams CL, 35. Gu Y, Lin S, Li JL, Nakagawa H, Chen Z, Jin B, Tian L,
Prenen H, Briggs S, Harrison R, Sanders S, Macdonald D, Ucar DA, Shen H, Lu J, Hochwald SN, Kaye FJ, Wu L. Altered
Haigh C, Tucker A, Love S, Nanji M, DeCaestecker J, LKB1/CREB-regulated transcription co-activator (CRTC)
Ferry D, Rathbone B, Hapeshi J, Barr H, Moayyedi P, signaling axis promotes esophageal cancer cell migration and
Watson P, Zietek B, Maroo N, Gay L, Underwood T, invasion. Oncogene 2012;31:469-79.
Boulter L, McMurtry H, Monk D, Patel P, Ragunath K, 36. Woo J, Miletich I, Kim BM, Sharpe PT, Shivdasani RA.
Al Dulaimi D, Murray I, Koss K, Veitch A, Trudgill N, Barx1-mediated inhibition of Wnt signaling in the mouse
Nwokolo C, Rembacken B, Atherfold P, Green E, Ang Y, thoracic foregut controls tracheo-esophageal septation and
Kuipers EJ, Chow W, Paterson S, Kadri S, Beales I, epithelial differentiation. PLoS One 2011;6:E22493.
Grimley C, Mullins P, Beckett C, Farrant M, Dixon A, 37. Miletich I, Buchner G, Sharpe PT. Barx1 and evolutionary
Kelly S, Johnson M, Wajed S, Dhar A, Sawyer E, Roylance R, changes in feeding. J Anat 2005;207:619-22.
Onstad L, Gammon MD, Corley DA, Shaheen NJ, Bird NC, 38. Logan CY, Nusse R. The Wnt signaling pathway in development
Hardie LJ, Reid BJ, Ye W, Liu G, Romero Y, Bernstein L, and disease. Annu Rev Cell Dev Biol 2004;20:781-810.
Wu AH, Casson AG, Fitzgerald R, Whiteman DC, Risch HA, 39. Yamamoto S, Nakase H, Matsuura M, Honzawa Y,
Levine DM, Vaughan TL, Verhaar AP, van den Brande J, Matsumura K, Uza N, Yamaguchi Y, Mizoguchi E, Chiba T.
Toxopeus EL, Spaander MC, Wijnhoven BP, van der Laan LJ, Heparan sulfate on intestinal epithelial cells plays a critical role
Krishnadath K, Wijmenga C, Trynka G, McManus R, in intestinal crypt homeostasis via Wnt/beta-catenin signaling.
Reynolds JV, O’Sullivan J, MacMathuna P, McGarrigle SA, Am J Physiol Gastrointest Liver Physiol 2013;305:G241-9.
Kelleher D, Vermeire S, Cleynen I, Bisschops R, Tomlinson I, 40. Niehrs C. The complex world of WNT receptor signalling. Nat
Jankowski J. Polymorphisms near TBX5 and GDF7 are Rev Mol Cell Biol 2012;13:767-79.
associated with increased risk for Barrett’s esophagus.
Gastroenterology 2015;148:367-78. 41. Blache P, van de Wetering M, Duluc I, Domon C, Berta P,
32. Su Z, Gay LJ, Strange A, Palles C, Band G, Whiteman DC, Freund JN, Clevers H, Jay P. SOX9 is an intestine crypt
Lescai F, Langford C, Nanji M, Edkins S, van der Winkel A, transcription factor, is regulated by the Wnt pathway,
Levine D, Sasieni P, Bellenguez C, Howarth K, Freeman C, and represses the CDX2 and MUC2 genes. J Cell Biol
2004;166:37-47.
Trudgill N, Tucker AT, Pirinen M, Peppelenbosch MP, van
der Laan LJ, Kuipers EJ, Drenth JP, Peters WH, Reynolds JV, 42. Ogaki S, Shiraki N, Kume K, Kume S. Wnt and Notch signals
Kelleher DP, McManus R, Grabsch H, Prenen H, Bisschops R, guide embryonic stem cell differentiation into the intestinal
Krishnadath K, Siersema PD, van Baal JW, Middleton M, lineages. Stem Cells 2013;31:1086-96.
Petty R, Gillies R, Burch N, Bhandari P, Paterson S, 43. Fortini ME. Notch signaling: the core pathway and its
Edwards C, Penman I, Vaidya K, Ang Y, Murray I, Patel P, posttranslational regulation. Dev Cell 2009;16:633-47.
Ye W, Mullins P, Wu AH, Bird NC, Dallal H, Shaheen NJ, 44. Galipeau PC, Li X, Blount PL, Maley CC, Sanchez CA,
Murray LJ, Koss K, Bernstein L, Romero Y, Hardie LJ, Odze RD, Ayub K, Rabinovitch PS, Vaughan TL, Reid BJ.
Zhang R, Winter H, Corley DA, Panter S, Risch HA, Reid BJ, NSAIDs modulate CDKN2A, TP53, and DNA content risk
Sargeant I, Gammon MD, Smart H, Dhar A, McMurtry H, for progression to esophageal adenocarcinoma. PLoS Med
Ali H, Liu G, Casson AG, Chow WH, Rutter M, Tawil A, 2007;4:E67.
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