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Page 8 of 14 Galli et al. J Cancer Metastasis Treat 2022;8:48 https://dx.doi.org/10.20517/2394-4722.2022.19

Figure 3. (A) False positive PET/CT with FDG-positive paratracheal LN suspicious for nodal metastasis. Histopathology did not reveal
any concrete LN alterations. (B) false negative PET/CT with histopathologically proven occult metastases in neck level II on the right
side.

Figure 4. (A) False positive MRI with suspicious LN metastasis in level II. Histopathology revealed sinus histiocytosis. (B) false negative
MRI with histopathologically proven occult metastasis in neck level II on the right side.

Early adverse events within 30 days after surgery were scored by the Clavien-Dindo Classification .
[19]
Eighteen patients (51.4%) showed no or grade I adverse events, 6 patients (17.1%) had grade II adverse
events including postoperative anemia with the need for blood transfusion or wound dehiscence treated
conservatively. Ten patients (28.6%) demonstrated grade III adverse events requiring surgical intervention
under general anesthesia, including bleeding or fistulae. One patient (2.9%) died within 30 days due to
severe wound dehiscence and superinfection (grade V). In six patients, no data on adverse events were
available, and these patients were not included in the percentage calculations. At the last follow-up,
persistent dysphagia was the only long-term sequelae noted in 15 patients (36.6%). Two of these 15 patients
developed tracheo-esophageal fistulas for which surgical repair was indicated.