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Galli et al. J Cancer Metastasis Treat 2022;8:48  https://dx.doi.org/10.20517/2394-4722.2022.19  Page 5 of 14

               Table 1. Patient demographics and initial tumor characteristics (n = 41)
                Feature                                                    Number of patients (%)
                Gender                          Male                       40 (97.6)
                                                Female                     1 (2.4)
                Initial tumor subsite           Supraglottic               9 (22.0)
                                                Glottic                    25 (61.0)
                                                Subglottic                 2 (4.9)
                                                Transglottic               5 (12.2)
                Initial clinical T classification  T1-2                    30 (73.2)
                                                T3-4                       11 (26.8)
                Initial clinical N classification  N0                      36 (87.8)
                                                N1                         2 (4.9)
                                                N2                         3 (7.3)
                Initial UICC staging            I-II                       29 (70.7)
                                                III-IV                     12 (29.3)
                Initial treatment               (C)RT                      39 (95.1)
                                                Primary surgery + (C)RT    1 (2.4)
                                                ND + (C)RT                 1 (2.4)
                Initial (C)RT                   Primary tumor RT           41 (100.0)
                                                Bilateral neck RT          22 (53.7)
                                                Only ipsilateral neck RT   2 (4.9)
                                                No neck RT                 16 (39)
                                                N/A**                      1 (2.4)

               (C)RT: Radiotherapy +/- concomitant chemotherapy; N/A: data not available; ND: neck dissection; UICC: union for international cancer control. *
               *Only with respect to neck irradiation.


               Table 2. Characteristics of recurrent laryngeal squamous cell carcinomas (n = 41)
                Feature                                                  Number of patients (%)
                Recurrence pT classification     T1-2                    8 (22.9)
                                                 T3-4                    27 (77.1)
                                                 N/A*                    6 (14.3)
                Recurrence pN classification     N0                      37 (90.2)
                                                 N1                      1 (2.4)
                                                 N2                      3 (7.3)
                UICC stage recurrence            I-II                    7 (19.4)
                                                 III-IV                  29 (80.6)
                                                 N/A*                    5 (11.2)
                Type of salvage surgery          STL + ND unilateral     7 (17.1)
                                                 STL + ND bilateral      34 (82.9)

               ND: Elective neck dissection; N/A: data not available; STL: salvage total laryngectomy; UICC: union for international cancer control. *The
               percentage of missing data was calculated using the total number of patients (n = 41), while the other percentages were calculated for the number
               of patients for whom data were available.


               Patterns of occult neck node metastases and diagnostic value of MRI and PET/CT in patients with
               recurrent LSCC undergoing STL
               For re-staging purposes, 35 (85.4%) patients underwent MRI, 35 (85.4%) underwent PET/CT, and 29
               (70.7 %) underwent both imaging modalities. The concordance between these two modalities with respect
               to rcN-staging was moderate (Cohen’s kappa = 0.47).
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