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Merhi et al. J Cancer Metastasis Treat 2021;7:42 Journal of Cancer
DOI: 10.20517/2394-4722.2021.80
Metastasis and Treatment

Original Article Open Access

The antiangiogenic phloroglucinol hyperforin
inhibits the secretion of proMMP-2, proMMP-9 and

VEGF-A during apoptosis of primary acute myeloid
leukemia cells

3,4
3
1,2
1
1,5
Faten Merhi , Ruoping Tang , Ollivier Legrand , Florence Nguyen-Khac , Santos A. Susin , Brigitte
Bauvois 1
1
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot,
Paris F-75006, France.
2
Department of Life & Earth Sciences, Faculty of Sciences (I), Lebanese University, Beirut, Lebanon.
3
Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Antoine, Service d’Hématologie Clinique, Paris F-75012,
France.
4
Service Génétique des Tumeurs, Département de Biologie et de Pathologie Médicale, Gustave Roussy Cancer Camus, Villejuif F-
94805, France.
5
Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Service d’Hématologie Biologique, Paris F-75013,
France.
Correspondence to: Dr. Brigitte Bauvois, Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université
Paris Descartes, Université Paris Diderot, 15 rue de l’Ecole de Médecine, Paris F-75006, France.
E-mail: brigitte.bauvois@crc.jussieu.fr
How to cite this article: Merhi F, Tang R, Legrand O, Nguyen-Khac F, Susin SA, Bauvois B. The antiangiogenic phloroglucinol
hyperforin inhibits the secretion of proMMP-2, proMMP-9 and VEGF-A during apoptosis of primary acute myeloid leukemia
cells. J Cancer Metastasis Treat 2021;7:42. https://dx.doi.org/10.20517/2394-4722.2021.80
Received: 29 May 2021 First Decision: 28 Apr 2021 Revised: 30 Apr 2021 Accepted: 28 May 2021 First online: 28 May 2021

Academic Editor: Lucio Miele Copy Editor: Yue-Yue Zhang Production Editor: Yue-Yue Zhang

Abstract
Aim: Angiogenesis is observed in acute myeloid leukemia (AML). AML cells abnormally proliferate and are
resistant to death. Positive regulators of angiogenesis, VEGF-A and matrix metalloproteinases (MMPs) 2 and 9 are
markers of disease status in AML. The natural phloroglucinol hyperforin (HF) displays antitumoral properties of
potential pharmacological interest. Herein, we investigated the effects of HF on MMP-2/9 and VEGF-A expression
and survival of primary AML cells.

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0
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