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Saier et al. J Cancer Metastasis Treat 2021;7:43 Journal of Cancer
DOI: 10.20517/2394-4722.2021.87
Metastasis and Treatment

Review Open Access

Bioactive lipids and cancer metastasis to bone

6
3,4
2,5
1,2
Lou Saier , Hira Niazi , Leyre Brizuela , Bodo Levkau , Olivier Peyruchaud 1,2
1
INSERM, Unit 1033, LYOS, Lyon 69372, France.
2
Université Claude Bernard Lyon 1, Lyon 69372, France.
3
INSERM Unit 970, Paris Cardiovascular Research Centre, Paris 75015, France.
4
Université de Paris, Paris 75015, France.
5
CNRS UMR 5246, INSA Lyon, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Lyon 69622, France.
6
Institute for Molecular Medicine III and University Hospital Düsseldorf, Düsseldorf, Heinrich Heine Universität, Düsseldorf
40225, Germany.
Correspondence to: Dr. Olivier Peyruchaud, INSERM Unit 1033, Université Claude Bernard Lyon 1, Lyon 69372, France.
E-mail: olivier.peyruchaud@inserm.fr
How to cite this article: Saier L, Niazi H, Brizuela L, Levkau B, Peyruchaud O. Bioactive lipids and cancer metastasis to bone. J
Cancer Metastasis Treat 2021;7:43. https://dx.doi.org/10.20517/2394-4722.2021.87
Received: 1 Apr 2021 Accepted: 6 May 2021 First online: 31 May 2021
Academic Editor: Lucio Miele Copy Editor: Yue-Yue Zhang Production Editor: Yue-Yue Zhang

Abstract
Bioactive lipids constitute a large family of molecules considered as inflammatory mediators. Among them,
lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), and eicosanoids (prostanoids such as PGE2 and
leukotrienes such as LTB4, LTC4, and LTD4) play a central role in the pathophysiology of several inflammatory
diseases. However, it has long been known that these bioactive lipids are also involved in cancer, mainly because of
their ability to control the pro-inflammatory microenvironment of tumors as well as their ability to act directly on
tumor cells promoting cell proliferation, migration, and survival. Recently, there has been increased interest in
determining how these lipid mediators orchestrate tumor development and metastasis. Bone metastases result
from a complex dialogue between tumor cells and bone cells. Recent findings demonstrate that all these bioactive
lipids can profoundly affect bone metabolism by acting positively or negatively on both osteoblasts and osteoclasts.
This review gives an overview of previous findings demonstrating direct involvement of LPA, S1P, and PGE2 in bone
metastasis. This review also emphasizes the recent findings that characterize the activity of these bioactive lipids
directly on bone cells and how these activities could be integrated into the complex molecular mechanisms leading
to bone metastasis formation and progression.

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
indicate if changes were made.

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