Page 36 - Read Online
P. 36
Sabol et al. J Cancer Metastasis Treat 2021;7:20 https://dx.doi.org/10.20517/2394-4722.2021.35 Page 13 of 15
2015;263:160-72. DOI PubMed
22. Siebel C, Lendahl U. Notch signaling in development, tissue homeostasis, and Disease. Physiol Rev 2017;97:1235-94. DOI PubMed
23. Bray SJ. Notch signalling in context. Nat Rev Mol Cell Biol 2016;17:722-35. DOI PubMed
24. Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009;137:216-33. DOI
PubMed PMC
25. Colombo M, Galletti S, Garavelli S, et al. Notch signaling deregulation in multiple myeloma: A rational molecular target. Oncotarget
2015;6:26826-40. DOI PubMed PMC
26. Komatsu H, Chao MY, Larkins-Ford J, et al. OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval
development. PLoS Biol 2008;6:e196. DOI PubMed PMC
27. Cordle J, Johnson S, Tay JZ, et al. A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-
inhibition. Nat Struct Mol Biol 2008;15:849-57. DOI PubMed PMC
28. Cordle J, Redfieldz C, Stacey M, et al. Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium
affinity. J Biol Chem 2008;283:11785-93. DOI PubMed
29. Raya A, Kawakami Y, Rodríguez-Esteban C, et al. Notch activity acts as a sensor for extracellular calcium during vertebrate left-right
determination. Nature 2004;427:121-8. DOI PubMed
30. Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 2006;7:678-89. DOI PubMed
31. D'Souza B, Miyamoto A, Weinmaster G. The many facets of Notch ligands. Oncogene 2008;27:5148-67. DOI PubMed PMC
32. Tetering G, Vooijs M. Proteolytic cleavage of Notch: "HIT and RUN". Curr Mol Med 2011;11:255-69. DOI PubMed PMC
33. Kitagawa M. Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators. J Biochem
2016;159:287-94. DOI PubMed
34. Kovall RA. More complicated than it looks: assembly of Notch pathway transcription complexes. Oncogene 2008;27:5099-109. DOI
PubMed
35. Borggrefe T, Oswald F. The Notch signaling pathway: Transcriptional regulation at Notch target genes. Cell Mol Life Sci
2009;66:1631-46. DOI PubMed
36. Aster JC, Pear WS, Blacklow SC. The varied roles of Notch in cancer. Annu Rev Pathol 2017;12:245-75. DOI PubMed PMC
37. Nowell CS, Radtke F. Notch as a tumour suppressor. Nat Rev Cancer 2017;17:145-59. DOI PubMed
38. Colombo M, Mirandola L, Platonova N, et al. Notch-directed microenvironment reprogramming in myeloma: a single path to
multiple outcomes. Leukemia 2013;27:1009-18. DOI PubMed
39. De Vos J, Couderc G, Tarte K, et al. Identifying intercellular signaling genes expressed in malignant plasma cells by using
complementary DNA arrays. Blood 2001;98:771-80. DOI PubMed
40. Jundt F, Pröbsting KS, Anagnostopoulos I, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells.
Blood 2004;103:3511-5. DOI PubMed
41. Skrtić A, Korać P, Krišto DR, Ajduković Stojisavljević R, Ivanković D, Dominis M. Immunohistochemical analysis of NOTCH1 and
JAGGED1 expression in multiple myeloma and monoclonal gammopathy of undetermined significance. Hum Pathol 2010;41:1702-
10. DOI PubMed
42. Houde C, Li Y, Song L, et al. Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients
and cell lines. Blood 2004;104:3697-704. DOI PubMed
43. Delgado-Calle J, Anderson J, Cregor MD, et al. Bidirectional Notch signaling and Osteocyte-derived factors in the bone marrow
microenvironment promote tumor cell proliferation and bone destruction in multiple myeloma. Cancer Res 2016;76:1089-100. DOI
PubMed PMC
44. Zhan F, Huang Y, Colla S, et al. The molecular classification of multiple myeloma. Blood 2006;108:2020-8. DOI PubMed PMC
45. Stralen E, van de Wetering M, Agnelli L, Neri A, Clevers HC, Bast BJ. Identification of primary MAFB target genes in multiple
myeloma. Exp Hematol 2009;37:78-86. DOI PubMed
46. Ordoñez R, Kulis M, Russiñol N, et al. Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple
myeloma. Genome Res 2020;30:1217-27. DOI PubMed PMC
47. Jundt F, Pröbsting KS, Anagnostopoulos I, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells.
Blood 2004;103:3511-5. DOI PubMed
48. Pisklakova A, Grigson E, Ozerova M, Chen F, Sullivan DM, Nefedova Y. Anti-myeloma effect of pharmacological inhibition of
Notch/gamma-secretase with RO4929097 is mediated by modulation of tumor microenvironment. Cancer Biol Ther 2016;17:477-85.
DOI PubMed PMC
49. Schwarzer R, Nickel N, Godau J, et al. Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM
model. Blood Cancer J 2014;4:e217. DOI PubMed PMC
50. Nefedova Y, Sullivan DM, Bolick SC, Dalton WS, Gabrilovich DI. Inhibition of Notch signaling induces apoptosis of myeloma cells
and enhances sensitivity to chemotherapy. Blood 2008;111:2220-9. DOI PubMed
51. Ramakrishnan V, Ansell S, Haug J, et al. MRK003, a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple
myeloma and non-Hodgkin's lymphoma. Leukemia 2012;26:340-8. DOI PubMed PMC
52. Zweidler-McKay PA, He Y, Xu L, et al. Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell
malignancies. Blood 2005;106:3898-906. DOI PubMed PMC
53. Colombo M, Galletti S, Bulfamante G, et al. Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-
6 expression in bone marrow niche. Oncotarget 2016;7:56013-29. DOI PubMed PMC
54. Li M, Chen F, Clifton N, et al. Combined inhibition of Notch signaling and Bcl-2/Bcl-xL results in synergistic antimyeloma effect.