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Availability of data and materials
The data that support the findings of this study are available from the corresponding author upon request.

Financial support and sponsorship
This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas “Integrative
Research on Cancer Microenvironment Networks from the Ministry of Education”, Culture, Sports, Science
and Technology of Japan” (Kizaka-Kondoh S), and Grant-in-Aid for Young Scientist (B) (Kuchimaru T).

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Male C3H mice were obtained from the Charles River Laboratory, Japan (Yokohama, Japan). All mice used
were 6-8 weeks of age and were housed in the animal facilities at the Tokyo Institute of Technology. Animal
experiments were performed with the approval of the Animal Ethics Committees of the Tokyo Institute of
Technology (No. D20170004-2) and in accordance with the Ethical Guidelines for Animal Experimentation
of the Tokyo Institute of Technology.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2020.

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