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Malone et al. J Cancer Metastasis Treat 2021;7:40 https://dx.doi.org/10.20517/2394-4722.2021.37 Page 13 of 18

without initial priming of the premetastatic niche. Further understanding of the components of the
premetastatic niche and how they work in concert is vital for more accurate predictions of metastatic
location and formation and may provide therapeutic targets.

DECLARATIONS
Acknowledgements
We would like to thank members of the Tsirka lab and especially Dr. Kaitlyn Thompson for advice and
suggestions for this review.

Author’s contributions
Co-wrote the review: Malone K, Tsirka SE

Availability of data and materials
Not applicable.

Financial support and sponsorship
Support was provided by T32GM0075186 (MKM) and TRO-Walk-for-Beauty Foundation Research Award
(SET).

Conflict of interest
Both authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
©The Author(s) 2021.

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