Page 70 - Read Online

Malone et al. J Cancer Metastasis Treat 2021;7:40 https://dx.doi.org/10.20517/2394-4722.2021.37 Page 17 of 18

2018;24:1024-35. DOI PubMed
111. Hosonaga M, Saya H, Arima Y. Molecular and cellular mechanisms underlying brain metastasis of breast cancer. Cancer Metastasis
Rev 2020;39:711-20. DOI PubMed PMC
112. Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol 2005;7:452-64. DOI PubMed
PMC
113. Cheng L, Huang Z, Zhou W, et al. Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth.
Cell 2013;153:139-52. DOI PubMed PMC
114. Cooke VG, LeBleu VS, Keskin D, et al. Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and
metastasis mediated by met signaling pathway. Cancer Cell 2012;21:66-81. DOI PubMed PMC
115. Keskin D, Kim J, Cooke VG, et al. Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2. Cell
Rep 2015;10:1066-81. DOI PubMed PMC
116. Molnár K, Mészáros Á, Fazakas C, et al. Pericyte-secreted IGF2 promotes breast cancer brain metastasis formation. Mol Oncol
2020;14:2040-57. DOI PubMed PMC
117. Lyle LT, Lockman PR, Adkins CE, et al. Alterations in pericyte subpopulations are associated with elevated blood-tumor barrier
permeability in experimental brain metastasis of breast cancer. Clin Cancer Res 2016;22:5287-99. DOI PubMed PMC
118. Zeng Q, Michael IP, Zhang P, et al. Synaptic proximity enables NMDAR signalling to promote brain metastasis. Nature
2019;573:526-31. DOI PubMed PMC
119. Schulz M, Salamero-Boix A, Niesel K, Alekseeva T, Sevenich L. Microenvironmental regulation of tumor progression and
therapeutic response in brain metastasis. Front Immunol 2019;10:1713. DOI PubMed PMC
120. Soto MS, Serres S, Anthony DC, Sibson NR. Functional role of endothelial adhesion molecules in the early stages of brain
metastasis. Neuro Oncol 2014;16:540-51. DOI PubMed PMC
121. Ng LG, Ostuni R, Hidalgo A. Heterogeneity of neutrophils. Nat Rev Immunol 2019;19:255-65. DOI PubMed
122. Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity.
Nat Rev Immunol 2011;11:519-31. DOI PubMed
123. Wu M, Ma M, Tan Z, Zheng H, Liu X. Neutrophil: a new player in metastatic cancers. Front Immunol 2020;11:565165. DOI
PubMed PMC
124. Zhang L, Yao J, Wei Y, et al. Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases. Sci Transl Med
2020;12:eaaz5387. DOI PubMed PMC
125. Hyun YM, Seo SU, Choi WS, et al. Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell-associated lung
inflammation. Sci Adv 2020;6:eabc4882. DOI PubMed PMC
126. Liu Y, Kosaka A, Ikeura M, et al. Premetastatic soil and prevention of breast cancer brain metastasis. Neuro Oncol 2013;15:891-903.
DOI PubMed PMC
127. Tomonobu N, Kinoshita R, Sakaguchi M. et al. S100 soil sensor receptors and molecular targeting therapy against them in cancer
metastasis. Transl Oncol 2020;13:100753. DOI PubMed PMC
128. Sinha P, Okoro C, Foell D, Freeze HH, Ostrand-Rosenberg S, Srikrishna G. Proinflammatory S100 proteins regulate the
accumulation of myeloid-derived suppressor cells. J Immunol 2008;181:4666-75. DOI PubMed PMC
129. Feinauer MJ, Schneider SW, Berghoff AS, et al. Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse
model. Blood 2021;137:1219-32. DOI PubMed
130. Malanchi I, Santamaria-Martínez A, Susanto E, et al. Interactions between cancer stem cells and their niche govern metastatic
colonization. Nature 2011;481:85-9. DOI PubMed
131. Fong MY, Zhou W, Liu L, et al. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote
metastasis. Nat Cell Biol 2015;17:183-94. DOI PubMed PMC
132. Balaj L, Lessard R, Dai L, et al. Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat
Commun 2011;2:180. DOI PubMed PMC
133. Skog J, Würdinger T, van Rijn S, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and
provide diagnostic biomarkers. Nat Cell Biol 2008;10:1470-6. DOI PubMed PMC
134. Théry C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 2009;9:581-93. DOI
PubMed
135. Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 2013;200:373-83. DOI PubMed
PMC
136. Peinado H, Lavotshkin S, Lyden D. The secreted factors responsible for pre-metastatic niche formation: old sayings and new
thoughts. Semin Cancer Biol 2011;21:139-46. DOI PubMed
137. Choi DS, Kim DK, Kim YK, Gho YS. Proteomics, transcriptomics and lipidomics of exosomes and ectosomes. Proteomics
2013;13:1554-71. DOI PubMed
138. Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel
mechanism of genetic exchange between cells. Nat Cell Biol 2007;9:654-9. DOI PubMed
139. Thakur BK, Zhang H, Becker A, et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res
2014;24:766-9. DOI PubMed PMC
140. Zhang L, Zhang S, Yao J, et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth.
Nature 2015;527:100-4. DOI PubMed PMC
141. Arnold J, Schattschneider J, Blechner C, et al. Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells is