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Page 6 of 13 Oliveira et al. Hepatoma Res 2020;6:xx I http://dx.doi.org/10.20517/2394-5079.2020.73
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Figure 2. Insulin resistance and insulin sensitivity in nonalcoholic fatty liver disease lean subjects vs. overweight vs.obese across regions.
A: lean subjects; B: overweight subjects; C: obese subjects
Clinical-laboratory-histological variability within similar weight strata
Lean subjects
Lean subjects in the US were also more likely to be hypertensive (55.6%) compared to those from Brazil
(33.3%), France (14.3%), and India (15.8%). Only 9.5% of lean US subjects had T2DM compared to 26%
of subjects in India and 66% of subjects in Brazil [Table 2]. There were no differences in the lipid profile of
lean subjects across the various cohorts. However, subjects in Brazil were more insulin resistant than those
in the other groups.
In line with greater IR, lean subjects from Brazil (mean grade 2.8) had a higher steatosis grade (P < 0.0005)
