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Jiang et al. Hepatoma Res 2020;6:52 Hepatoma Research
DOI: 10.20517/2394-5079.2020.47

Systematic Review Open Access

Global pattern and trend of liver cancer survival: a
systematic review of population-based studies

Yu-Fei Jiang 1,2,3 , Zhuo-Ying Li , Xiao-Wei Ji , Qiu-Ming Shen , Jia-Yi Tuo , Hui-Yun Yuan , Yong-Bing
1,2
3
1,2
1,2
1,2
Xiang 1,2,3
1 School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
2 State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital,
Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
3 Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
Correspondence to: Prof. Yong-Bing Xiang, State Key Laboratory of Oncogenes and Related Genes & Department of Epidemiology,
Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, No. 25, Lane 2200, Xie Tu Road,
Shanghai 200032, China. E-mail: ybxiang@shsci.org
How to cite this article: Jiang YF, Li ZY, Ji XW, Shen QM, Tuo JY, Yuan HY, Xiang YB. Global pattern and trend of liver cancer
survival: a systematic review of population-based studies. Hepatoma Res 2020;6:52.
http://dx.doi.org/10.20517/2394-5079.2020.47

Received: 3 May 2020 First Decision: 1 Jun 2020 Revised: 15 Jun 2020 Accepted: 28 Jun 2020 Published: 15 Aug 2020
Academic Editor: Guang-Wen Cao Copy Editor: Cai-Hong Wang Production Editor: Jing Yu
Received: First Decision: Revised: Accepted: Published:

Science Editor: Copy Editor: Production Editor: Jing Yu
Abstract
Aim: To describe the global pattern and trend of liver cancer survival, using data from the population-based studies
or cancer registration.

Methods: By searching CNKI, Wanfang Data, PubMed, Web of Science, EMBASE and SEER. All population-based
survival studies of liver cancer from 1 January 2000 to 30 April 2020 were collected and evaluated by patient
gender, time period, and country. The overall or age-standardized five-year relative survival rate was used to
describe the pattern and changes in liver cancer survival over the past decades.

Results: Globally, the highest age-standardized five-year relative survival rate was observed in Italy (18.0%, 2005-
2007) and the highest overall five-year relative survival rate was observed in Korea (34.6%, 2012-2016), when
compared to other countries. The most remarkable increase in overall five-year relative survival rate can be seen
in Korea (from 10.7% during 1993-1995 to 34.6% during 2012-2016). In general, worldwide, the five-year relative
survival rate of younger patients with liver cancer was higher than old people. For most countries, the five-year
relative survival rate of liver cancer was slightly higher in women than in men. In China, the overall five-year
relative survival rate of liver cancer in Taiwan was higher than that in other areas, while Cixian of Hebei and Qidong
of Jiangsu were lower.

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

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