Page 147 - Read Online

Page 8 of 11 Tsutsui et al. Hepatoma Res 2018;4:13 I http://dx.doi.org/10.20517/2394-5079.2018.20

Table 6. Histopathology of resected livers: treatment group versus control group
Variables Treatment group (n = 13) Control group (n = 36) P
Tumor size (mm)* 27 (14-50) 25 (10-58) 0.666
Number of tumor (n)* 1.0 (1-2) 1.0 (1-3) 0.560
Microscopic vascular invasion 3 18 0.131
Intrahepatic metastasises 5 10 0.476
Gross classification
SN/SNEG/CMN 4/4/4 7/21/8 0.535
Histologic grade 0.202
Well differentiated 1 1
Moderately differentiated 8 32
Poorly differentiated 3 3
Liver cirrhosis** 0.227
F0 2 3
F1-F2 6 8
F3-F4 5 25
JBCS
Grade 0 3 -
Grade 1 (1a/1b) 3/3 -
Grade 2 (2a/2b) 2/1 -
Grade 3 1 -
*Median with range; **new Inuyama classification. SN: simple nodular type; SNEG: simple nodular type with extranodular growth; CMN:
confluent mutinodular type; JBCS: Japanese Brest Cancer Society

Figure 2. Overall survival curves after hepatic resection in the treatment group (dashed line) and the control groups (solid line)

The regimen selected for this study was 2 weeks of low-dose FP. Ishikawa et al. [29,30] first reported that
HAIC with cisplatin before radical local treatment (radiofrequency ablation/percutaneous ethanol injection
therapy) for early-stage HCC prevented intrahepatic metastasis and prolonged the survival time. According
[28]
to some clinical studies, the efficacy of low-dose FP is better than that of cisplatin alone . Ueshima et al.
[31]
reported that HAIC using low-dose FP (continuous arterial infusion of 5-FU and cisplatin for the first
2 weeks followed by a single dose of cisplatin and 5-FU once a week) is an effective treatment for locally
advanced HCC. In our experience, almost all HAIC responders exhibited a decrease in tumor marker ratios
in the early stage of treatment; thus, we believe 2 weeks of low-dose FP was sufficient to observe the effect of
chemotherapy. HAIC-related liver toxicity is caused by complications associated with catheter placement,
such as catheter dislocation, hepatic artery occlusion and stenosis, and infection. The 2-week regimen