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El-Gazzar et al. Hepatoma Res 2017;3:123-8 Hepatoma Research
DOI: 10.20517/2394-5079.2017.08
www.hrjournal.net
Original Article Open Access

Use of gadobenate dimeglumine dynamic

MRI for detection of early hepatocellular

carcinoma in atypical hepatic focal lesions

Mohamed F. El-Gazzar , Mohamed Ahmed Samy Kohla , Mahmoud M. El-Sakhawy , Mohamed M. Husseiny , Reda
3
3
1
2
R. H. Yousef , Safinaz H. El-Shorbagy
5
4
1 Department of Oncology, National Liver Institute, Menoufia University, Shebeen El-Kom 32511, Egypt.
2 Department of Hepatology, National Liver Institute, Menoufia University, Shebeen El-Kom 32511, Egypt.
3 Department of Radiology, National Liver Institute, Menoufia University, Shebeen El-Kom 32511, Egypt.
4 Department of Radiodiagnosis, Faculty of Medicine, Al-Azhar University, Cairo 11651, Egypt.
5 Department of Pathology, Faculty of Medicine, Tanta University, Tanta 31111, Egypt.
Correspondence to: Dr. Mohamed Ahmed Samy Kohla, Department of Hepatology, National Liver Institute, Menoufia University, Shebeen El-Kom
32511, Egypt. E-mail: dr_mohamedsamy@yahoo.com
How to cite this article: El-Gazzar MF, Kohla MAS, El-Sakhaw MM, Husseiny MM, Yousef RRH, El-Shorbagy SH. Use of gadobenate dimeglumine
dynamic MRI for detection of early hepatocellular carcinoma in atypical hepatic focal lesions. Hepatoma Res 2017;3:123-8.

ABSTRACT
Article history: Aim: Gadobenate dimeglumine (multihance) is a contrast medium which can be used not
Received: 16-03-2017 only as an extracellular contrast agent for dynamic imaging of the liver, but also as a liver
Accepted: 09-05-2017 specific agent for the acquisition of hepatobiliary-phase images which are more helpful in
Published: 26-06-2017 evaluation of small atypical hepatic focal lesions equal or less than 3 cm. The authors tried
to evaluate multihance dynamic magnetic resonance imaging (MRI) as a new modality in
Key words: early detection of hepatocellular carcinoma (HCC). Methods: Thirty cirrhotic patients with
Dynamic magnetic resonance small hepatic focal lesions (less than 3 cm in diameter), detected by imaging (ultrasound and
imaging, triphasic computed tomography) were subjected to dynamic MRI with multihance contrast.
multihance, All patients had a liver biopsy stained with heat shock protein 70, glypican 3, and glutamine
gadobenate dimeglumine, synthetase to confirm the diagnosis of HCC. Results: Eight out of 30 patients (26.6%) with
early detection, atypical focal lesions proved to have HCC by histology, whereas 7 out of 8 histologically
hepatocellular carcinoma proven HCC patients (87.5%) were shown to have typical criteria on Multihance imaging.
Conclusion: Multihance dynamic MRI is a promising diagnostic modality for detection of
early HCC, however, future studies on large numbers of patients are warranted to precisely
detect the sensitivity and specificity of this new modality.

INTRODUCTION developing countries where hepatitis B and hepatitis C
[2]
viruses are endemic. Cirrhosis is the most important
Hepatocellular carcinoma (HCC) is the most common risk factor for HCC; overall, one third of cirrhotic patients
[3]
primary tumor of the liver with a global incidence of will develop HCC during their life time. Portal supply
[1]
approximately half a million cases per year. It is gradually decreases in accordance with higher grades
a rapidly fatal cancer that mostly affects persons in of malignancy of the nodules and finally disappears in
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