Page 56 - Read Online

Original Article

Predictive factors for the success of “one-off” ablation in

single hepatocellular carcinoma patients who underwent
percutaneous radiofrequency ablation

Jian-Yun Long, Jing Li, Jie Cao, Liang Huang, Xiang-Hua Zhang, Jin-Kai Liu, Yi-Qun Yan
Department of Hepatic Surgery I, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438,
China

ABSTRACT
Aim: To investigate the technique’s effectiveness and evaluate the risk factors affecting the success of “one-off”
percutaneous ultrasound-guided radiofrequency ablation (RFA) for single hepatocellular carcinoma (HCC). Methods:
A total of 462 consecutive patients who received RFA from February 2010 to December 2013 at a single center
(Eastern Hepatobiliary Surgery Hospital, Shanghai, China) were enrolled in the study. The patients were followed
up for at least 6 months. Herein, this study adopted a new terminology named “one-off” ablation which is defined
as achieving complete necrosis and no local residual or recurrent tumor within 6 months after single-session RFA.
The incidence of “one-off” RFA was observed and the attributing risk factors were analyzed. A multivariate analysis
was conducted to determine the independent predictive factors for the success of “one-off” ablation. Results: The
technique’s effectiveness was 90.0% (416/462). After 6 months, 281 patients achieved “one-off” ablation, while 181
patients failed. On univariate analysis, tumor size ≤ 3 cm and tumor further from organs were found to be significantly
correlated with “one-off” complete ablation (P = 0.003, and P = 0.010, respectively). On multivariate analysis using a
logistic regression, tumor size ≤ 3 cm [odds ratio (OR), 0.534; 95% confidence interval (CI): 0.346-0.825, P = 0.005]
and tumor further from organs (OR, 0.593; 95% CI: 0.387-0.909, P = 0.017) remained predictive. Conclusion: Tumor
size and tumor location are the predictive factors for the success of “one-off” ablation in patients with single HCC.
Key words: Hepatocellular carcinoma; radiofrequency ablation; tumor location; tumor size

Address for correspondence:
Prof. Yi-Qun Yan, Department of Hepatic Surgery I, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai
Road, Shanghai 200438, China. E-mail: ehbhyyq@163.com
Received: 03-09-2015, Accepted: 25-11-2015

INTRODUCTION in all the hepatic malignancies. Liver transplantation
(LT) and partial hepatectomy are considered as the
Liver cancer, one of the most fatal cancers, is the second main curative treatments for HCC. However, LT for
[2]
most common cancer in China. Each year, nearly 383,000 patients who meet the Milan criteria is limited due to
people died from liver cancer in China, which accounts the insufficient availability of donors. In addition,
[2]
for 51% of the deaths from liver cancer worldwide. anatomic location, multicentric tumor occurrence, and
[1]
Hepatocellular carcinoma (HCC) has the highest incidence This is an open access article distributed under the terms of the Creative
Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows
Access this article online others to remix, tweak, and build upon the work non-commercially, as long as the
Quick Response Code author is credited and the new creations are licensed under the identical terms.
Website: For reprints contact: service@oaepublish.com
http://www.hrjournal.net/
How to cite this article: Long JY, Li J, Cao J, Huang L, Zhang XH, Liu
DOI: JK, Yan YQ. Predictive factors for the success of "one-off" ablation in
10.4103/2394-5079.172726 single hepatocellular carcinoma patients who underwent percutaneous
radiofrequency ablation. Hepatoma Res 2016;2:47-52.

© 2016 Hepatoma Research | Published by OAE Publishing Inc. 47