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function which may make prognosis even worse. Further of laparoscopic radiofrequency ablation for HCC. Could the location
prospective randomized controlled trials with larger sample of the tumour infl uence a complete response to treatment? A single
European centre experience. HPB (Oxford) 2015;17:387-93.
sizes should focus on combining RFA with therapies like TACE 10. Lee SD, Han HS, Cho JY, Yoon YS, Hwang DW, Jung K, Yoon CJ,
in order to decrease local tumor progression. Kwon Y, Kim JH. Safety and effi cacy of laparoscopic radiofrequency
ablation for hepatic malignancies. J Korean Surg Soc 2012;83:36-42.
As a conclusion, laparoscopic RFA of HCC is a safe and 11. Santambrogio R, Podda M, Zuin M, Bertolini E, Bruno S, Cornalba GP,
effective curative strategy in selected patients with Costa M, Montorsi M. Safety and effi cacy of laparoscopic radiofrequency
ablation of hepatocellular carcinoma in patients with liver cirrhosis. Surg
unresectable disease, especially when the percutaneous Endosc 2003;17:1826-32.
approach is very difficult. In combination with ultrasound, 12. Dindo D, Demartines N, Clavien PA. Classification of surgical
this technique offers clear advantages over other approaches. complications: a new proposal with evaluation in a cohort of
6336 patients and results of survey. Ann Surg 2004;240:205-13.
The incidence of major complications within 30 days after 13. Tiong LU, Filed JB, Maddern GJ. Bimodal electric tissue ablation (BETA)
the procedure is very low and the long-term outcomes are compared with the Cool-Tip RFA system. ANZ J Surg 2012;82:269-74.
similar to those achieved with liver resection. Further trials 14. Boas FE, Do B, Louie JD, Kothary N, Hwang GL, Kuo WT,
are needed to assess long-term results in terms of local Hovsepian DM, Kantrowitz M, Sze DY. Optimal imaging surveillance
recurrence and survival. schedules after liver-directed therapy for hepatocellular carcinoma.
J Vasc Interv Radiol 2015;26:69-73.
15. Cillo U, Vitale A, Dupuis D, Corso S, Neri D, D’Amico F, Gringeri E,
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9. de la Serna S, Vilana R, Sánchez-Cabús S, Calatayud D, Ferrer J, Source of Support: Nil. Confl ict of Interest: None declared.
Molina V, Fondevila C, Bruix J, Fuster J, García-Valdecasas JC. Results

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