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Yu et al. Hepatoma Res. 2025;11:29 | https://dx.doi.org/10.20517/2394-5079.2025.47 Page 9 of 12

Figure 3. Calibration curve of the nomogram prediction model for severe immunotherapy-related adverse events in HCC patients. HCC:
Hepatocellular carcinoma.

Table 4. ROC values of clinical indicators and the predictive model

Variable AUC 95%CI Sensitivity Specificity Cut-off
Model 0.885 0.820-0.951 0.812 0.889 137.786
Cirrhosis 0.678 0.595-0.762 0.624 0.733 0.5
NLR 0.793 0.711-0.874 0.718 0.844 2.55
Treg 0.713 0.615-0.811 0.812 0.578 5.1
Lymphocytes 0.717 0.610-0.824 0.788 0.733 31.75
Cr 0.661 0.566-0.757 0.729 0.600 56.4
ROC: Receiver operating characteristic; AUC: area under the ROC curve; CI: confidence interval; NLR: neutrophil-to-lymphocyte ratio; Treg:
regulatory T cell; Cr: creatinine.