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Financial support and sponsorship
This work was supported by funding from Good Ventures/Open Philanthropy (to Walt DR ), and The
Genetics Guided Dementia Discovery Platform of Eisai Inc. (to Walt DR ). Work on “Brain-Derived
Extracellular Vesicles for Analysis of Treatment Resistant Major Depressive Disorder” is supported by
Wellcome Leap as part of the Multi-Channel Psych Program (to Walt DR). These funding agencies had no
role in conceptualization, design, analysis, decision to publish, or preparation of this manuscript.

Conflict of interests
Shami-shah A, Travis BG declare no known conflicts of interest. Walt DR has a financial interest in
Quanterix, a company developing an ultrasensitive digital immunoassay platform; he is an inventor of the
Simoa technology, a founder of the company, and a member of its board of directors. Walt DR ’s interests
are reviewed and managed by BWH and Partners HealthCare in accordance with their conflict-of-interest
policies.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
©The Author(s) 2023.

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