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Gurska et al. Cancer Drug Resist 2023;6:674-87 https://dx.doi.org/10.20517/cdr.2023.39 Page 684

transplantation, such as characterizing TIL populations prior to and during treatment, or examining T cell
and NK cell numbers and function in specific molecular or cytogenetic subgroups of AML will pave the way
for more personalized AML treatment plans.

DECLARATIONS
Authors’ contributions
Wrote, reviewed, and edited the manuscript: Gurska L, Gritsman K.

Availability of data and materials
Not applicable.

Financial support and sponsorship
This work was supported by the National Institutes of Health (NIH) Grants R01CA196973 (Gritsman K)
and F31CA247172 (Gurska L). This content is solely the responsibility of the authors and does not
necessarily represent the official views of the National Institutes of Health. This work was also supported by
a Research Scholar Grant RSG-19-130-01-DDC from the American Cancer Society to Kira Gritsman, MD,
PhD.

Conflicts of interest
Gritsman K has received research funding from ADC Therapeutics and iOnctura. Gurska L declares that
there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2023.

REFERENCES
1. American Cancer Society. Cancer Facts & Figures 2023. Available from: https://www.cancer.org/research/cancer-facts-statistics/all-
cancer-facts-figures/2023-cancer-facts-figures.html. [Last accessed on 22 Sep 2023].
2. Shlush LI, Feldman T. The evolution of leukaemia from pre-leukaemic and leukaemic stem cells. J Intern Med 2021;289:636-49. DOI
PubMed
3. Pollyea DA, Jordan CT. Therapeutic targeting of acute myeloid leukemia stem cells. Blood 2017;129:1627-35. DOI
4. Corces-Zimmerman MR, Hong WJ, Weissman IL, Medeiros BC, Majeti R. Preleukemic mutations in human acute myeloid leukemia
affect epigenetic regulators and persist in remission. Proc Natl Acad Sci U S A 2014;111:2548-53. DOI PubMed PMC
5. Gurska LM, Ames K, Gritsman K. Signaling pathways in leukemic stem cells. Adv Exp Med Biol 2019;1143:1-39. DOI PubMed
PMC
6. Velten L, Story BA, Hernández-Malmierca P, et al. Identification of leukemic and pre-leukemic stem cells by clonal tracking from
single-cell transcriptomics. Nat Commun 2021;12:1366. DOI PubMed PMC
7. Ng SW, Mitchell A, Kennedy JA, et al. A 17-gene stemness score for rapid determination of risk in acute leukaemia. Nature
2016;540:433-7. DOI
8. van Galen P, Hovestadt V, Wadsworth Ii MH, et al. Single-cell RNA-Seq reveals AML hierarchies relevant to disease progression and
immunity. Cell 2019;176:1265-81.e24. DOI PubMed PMC
9. Eppert K, Takenaka K, Lechman ER, et al. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat
Med 2011;17:1086-93. DOI
10. Pandolfi A, Barreyro L, Steidl U. Concise review: preleukemic stem cells: molecular biology and clinical implications of the
precursors to leukemia stem cells. Stem Cells Transl Med 2013;2:143-50. DOI PubMed PMC
11. Newell LF, Cook RJ. Advances in acute myeloid leukemia. BMJ 2021;375:n2026. DOI PubMed
12. Tallman MS, Wang ES, Altman JK, et al. Acute myeloid leukemia, version 3.2019, NCCN clinical practice guidelines in oncology. J