Page 92 - Read Online

Page 18 of 20 Choi et al. Cancer Drug Resist. 2026;9:12

7. Bilston LE, Fletcher DF, Brodbelt AR, Stoodley MA. Arterial pulsation-driven cerebrospinal fluid flow in the perivascular space: a
computational model. Comput Methods Biomech Biomed Engin. 2003;6:235-41. DOI PubMed
8. Kelley DH, Thomas JH. Cerebrospinal fluid flow. Annu Rev Fluid Mech. 2023;55:237-64. DOI PubMed PMC
9. Alshuhri MS, Gallagher L, Work LM, Holmes WM. Direct imaging of glymphatic transport using H217O MRI. JCI Insight.
2021;6:141159. DOI PubMed PMC
10. Peng S, Liu J, Liang C, Yang L, Wang G. Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders.
Neurobiol Dis. 2023;179:106035. DOI PubMed
11. Chen W, Liang C, Peng S, et al. Aquaporin-4 activation facilitates glymphatic system function and hematoma clearance
post-intracerebral hemorrhage. Glia. 2025;73:368-80. DOI PubMed PMC
12. Wichmann TO, Damkier HH, Pedersen M. A brief overview of the cerebrospinal fluid system and its implications for brain and spinal
cord diseases. Front Hum Neurosci. 2021;15:737217. DOI PubMed PMC
13. Gomolka RS, Hablitz LM, Mestre H, et al. Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid
stagnation. Elife. 2023;12:e82232. DOI PubMed PMC
14. Iliff JJ, Chen MJ, Plog BA, et al. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J
Neurosci. 2014;34:16180-93. DOI PubMed PMC
15. Holth JK, Fritschi SK, Wang C, et al. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science.
2019;363:880-4. DOI PubMed PMC
16. Harrison IF, Ismail O, Machhada A, et al. Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model. Brain.
2020;143:2576-93. DOI PubMed PMC
17. Mortensen KN, Sanggaard S, Mestre H, et al. Impaired glymphatic transport in spontaneously hypertensive rats. J Neurosci.
2019;39:6365-77. DOI PubMed PMC
18. Benveniste H, Lee H, Volkow ND. The glymphatic pathway: waste removal from the CNS via cerebrospinal fluid transport.
Neuroscientist. 2017;23:454-65. DOI PubMed PMC
19. Louveau A, Plog BA, Antila S, Alitalo K, Nedergaard M, Kipnis J. Understanding the functions and relationships of the glymphatic
system and meningeal lymphatics. J Clin Invest. 2017;127:3210-9. DOI PubMed PMC
20. Zhao L, Tannenbaum A, Bakker ENTP, Benveniste H. Physiology of glymphatic solute transport and waste clearance from the brain.
Physiology. 2022;37:349-62. DOI PubMed PMC
21. Li G, Cao Y, Tang X, Huang J, Cai L, Zhou L. The meningeal lymphatic vessels and the glymphatic system: potential therapeutic targets
in neurological disorders. J Cereb Blood Flow Metab. 2022;42:1364-82. DOI PubMed PMC
22. Benveniste H, Liu X, Koundal S, Sanggaard S, Lee H, Wardlaw J. The glymphatic system and waste clearance with brain aging: a
review. Gerontology. 2019;65:106-19. DOI PubMed PMC
23. Peng W, Achariyar TM, Li B, et al. Suppression of glymphatic fluid transport in a mouse model of Alzheimer’s disease. Neurobiol Dis.
2016;93:215-25. DOI PubMed PMC
24. Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018;17:1016-24. DOI
PubMed PMC
25. Gao Y, Liu K, Zhu J. Glymphatic system: an emerging therapeutic approach for neurological disorders. Front Mol Neurosci.
2023;16:1138769. DOI PubMed PMC
26. Lilius TO, Mortensen KN, Deville C, et al. Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles. J
Control Release. 2023;355:135-48. DOI PubMed
27. Zhang R, Li J, Li X, Zhang S. Therapeutic approaches to CNS diseases via the meningeal lymphatic and glymphatic system: prospects
and challenges. Front Cell Dev Biol. 2024;12:1467085. DOI PubMed PMC
28. Calias P, Banks WA, Begley D, Scarpa M, Dickson P. Intrathecal delivery of protein therapeutics to the brain: a critical reassessment.
Pharmacol Ther. 2014;144:114-22. DOI PubMed
29. Fowler MJ, Cotter JD, Knight BE, Sevick-Muraca EM, Sandberg DI, Sirianni RW. Intrathecal drug delivery in the era of nanomedicine.
Adv Drug Deliv Rev. 2020;165-6:77-95. DOI PubMed PMC
30. Schreiner TG, Menéndez-González M, Schreiner OD, Ciobanu RC. Intrathecal therapies for neurodegenerative diseases: a review of
current approaches and the urgent need for advanced delivery systems. Biomedicines. 2025;13:2167. DOI PubMed PMC
31. Toh CH, Siow TY. Factors associated with dysfunction of glymphatic system in patients with glioma. Front Oncol. 2021;11:744318.
DOI PubMed PMC
32. Ma Q, Schlegel F, Bachmann SB, et al. Lymphatic outflow of cerebrospinal fluid is reduced in glioma. Sci Rep. 2019;9:14815. DOI
PubMed PMC
33. Formolo DA, Yu J, Lin K, et al. Leveraging the glymphatic and meningeal lymphatic systems as therapeutic strategies in Alzheimer’s
disease: an updated overview of nonpharmacological therapies. Mol Neurodegener. 2023;18:26. DOI PubMed PMC
85