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Page 10 of 10 Zierke et al. Rare Dis Orphan Drugs J 2023;2:10 https://dx.doi.org/10.20517/rdodj.2022.17

trypsinogen in acinar cells in acute pancreatitis. J Leukoc Biol 2012;91:711-9. DOI PubMed
61. Mcguire M, Lipsky P, Thiele D. Generation of active myeloid and lymphoid granule serine proteases requires processing by the
granule thiol protease dipeptidyl peptidase I. Journal of Biological Chemistry 1993;268:2458-67. DOI PubMed
62. Turk D, Janjić V, Stern I, et al. Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase
framework creates the machine for activation of granular serine proteases. EMBO J 2001;20:6570-82. DOI PubMed PMC
63. Adkison AM, Raptis SZ, Kelley DG, Pham CT. Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the
development of acute experimental arthritis. J Clin Invest 2002;109:363-71. DOI PubMed PMC
64. Mayerle J, Schnekenburger J, Krüger B, et al. Extracellular cleavage of E-cadherin by leukocyte elastase during acute experimental
pancreatitis in rats. Gastroenterology 2005;129:1251-67. DOI
65. Aghdassi AA, John DS, Sendler M, et al. Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte
infiltration but does not change the severity of acute pancreatitis. Sci Rep 2019;9:16774. DOI PubMed PMC
66. Leppkes M, Maueröder C, Hirth S, et al. Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives
pancreatitis. Nat Commun 2016;7:10973. DOI PubMed PMC
67. Merza M, Hartman H, Rahman M, et al. Neutrophil extracellular traps induce trypsin activation, inflammation, and tissue damage in
mice with severe acute pancreatitis. Gastroenterology 2015;149:1920-1931.e8. DOI
68. Geisz A, Sahin-Tóth M. A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation. Nat Commun 2018;9:5033.
DOI PubMed PMC
69. Archer H, Jura N, Keller J, Jacobson M, Bar-Sagi D. A mouse model of hereditary pancreatitis generated by transgenic expression of
R122H trypsinogen. Gastroenterology 2006;131:1844-55. DOI PubMed
70. Mitsuyama T, Uchida K, Sumimoto K, et al. Comparison of neutrophil infiltration between type 1 and type 2 autoimmune pancreatitis.
Pancreatology 2015;15:271-80. DOI
71. Marinaccio L, Stefanucci A, Scioli G, et al. Peptide human neutrophil elastase inhibitors from natural sources: an overview. Int J Mol
Sci 2022;23:2924. DOI PubMed PMC
72. Sjö P. Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors. Future
Med Chem 2012;4:651-60. DOI PubMed
73. Cao C, Yin C, Shou S, et al. Ulinastatin protects against LPS-induced acute lung injury by attenuating TLR4/NF-κB pathway
activation and reducing inflammatory mediators. Shock 2018;50:595-605. DOI
74. Testoni PA, Mariani A, Masci E, Curioni S. Frequency of post-ERCP pancreatitis in a single tertiary referral centre without and with
routine prophylaxis with gabexate: a 6-year survey and cost-effectiveness analysis. Dig Liver Dis 2006;38:588-95. DOI
75. Cao J, Liu Q. Protective effects of sivelestat in a caerulein-induced rat acute pancreatitis model. Inflammation 2013;36:1348-56. DOI
76. Wang H, Wang S, Tang A, Gong H, Ma P, Chen L. Combined effects of sivelestat and resveratrol on severe acute pancreatitis-
associated lung injury in rats. Exp Lung Res 2014;40:288-97. DOI
77. Dobschuetz E, Hoffmann T, Messmer K. Inhibition of neutrophil proteinases by recombinant serpin Lex032 reduces capillary no-
reflow in ischemia/reperfusion-induced acute pancreatitis. J Pharmacol Exp Ther 1999;290:782-8. PubMed