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Qin et al. Vessel Plus 2020;4:2 Vessel Plus
DOI: 10.20517/2574-1209.2019.22

Original Article Open Access

The intracoronary injection of recombinant human
prourokinase in emergency interventional therapy

for high thrombus load during ST-segment elevation
myocardial infarction: a retrospective cohort study

Zuo-An Qin , Xue-Lin Lu , Quan Zhou , Li Luo , Zhi-Xiang Zhan , Ning Guo , Liang-Qing Ge 1
3
1
2
1
1
1
1 Department of Cardiology, The First People’s Hospital of Changde City, Changde 415003, Hunan, China.
2 Department of Pathology, The First People’s Hospital of Changde City, Changde 415003, Hunan, China.
3 Department of Science and Education, The First People’s Hospital of Changde City, Changde 415003, Hunan, China.
Correspondence to: Liang-Qing Ge, Department of Cardiology, The First People’s Hospital of Changde City, Changde 415003,
Hunan, China. E-mail: geliangqing@163.com
How to cite this article: Qin ZA, Lu XL, Zhou Q, Luo L, Zhan ZX, Guo N, Ge LQ. The intracoronary injection of recombinant human
prourokinase in emergency interventional therapy for high thrombus load during ST-segment elevation myocardial infarction: a
retrospective cohort study. Vessel Plus 2020;4:2. http://dx.doi.org/10.20517/2574-1209.2019.22

Received: 6 Jul 2019 First Decision: 23 Sep 2019 Revised: 17 Dec 2019 Accepted: 15 Jan 2020 Published: 12 Feb 2020

Science Editor: Cristiano Spadaccio Copy Editor: Jing-Wen Zhang Production Editor: Tian Zhang

Abstract
Aim: The clinical effect of the injection of recombinant human prourokinase to infarction-related arteries during
percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) patients who have slow
reflow/no reflow was investigated.

Methods: Data from STEMI patients who underwent emergency PCI at the Chest Pain Center of the First People’s
Hospital of Changde City from April 2017 to December 2018 were collected for analysis.

Results: Whether the ST segment had decreased by more than 50% at 90 min and whether the creatine kinase
isoenzyme and cardiac troponin I had decreased by more than 50% were investigated. There were no significant
differences in the indexes of color Doppler echocardiography (left ventricular ejection fraction, left ventricular end-
diastolic diameter, ventricular aneurysm, and ventricular thrombus) within seven days after surgery and in the
ventricular tachycardia/ventricular fibrillation between the two groups (P > 0.05). There was no significant difference in
major adverse cardiovascular event between the two groups within one month after surgery (P > 0.05), but, there were
significant differences in the Thrombolysis in Myocardial Infarction (TIMI) classification, corrected TIMI frame count,
creatine kinase peak value, and the third-degree atrioventricular block (P < 0.05).

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

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