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Tumscitz et al. Vessel Plus 2019;3:20 I http://dx.doi.org/10.20517/2574-1209.2018.71 Page 7 of 8

On the other hand when the bleeding site is very close to major branches, coiling is always preferable because
risk of inadvertent vascular embolization is not negligible, though coiling is definitely more onerous and
time-consuming [34,35] .

Another point in favor of (NBCA-MS)-based glue is his ability to create a sort of wide patch of polymeric
material around the rupture that can cover different size of coronary perforations. This could be of adjunctive
help in epicardial perforations when coiling from one side of the collateral could be not enough to stop
the bleeding, and coiling from the other side could be troublesome if the CTO is not recanalized. The
mechanism of the sealing in this setting could be explained with formation of aggregates of chain growth
polymers in the tissue around the spillage, along with the obstruction of the afferent vessel.

Interestingly no tissue adverse reactions was described after embolization despite the wide spectrum of
medical use of (NBCA-MS)-based glue.

DECLARATIONS
Authors’ contributions
All authors contributed to the manuscript.

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
All authors declared that there are no conflicts of interests.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

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