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lifestyle in more beneficial ecologic environment. On the other hand, it will also give a rise to earlier and
more focused medicinal preventive measures.

DECLARATIONS
Authors’ contributions
Concept of the study, general coordination and supervision of the research project, data analysis, statistical
analysis, and draft manuscript writing: Sobenin IA
Patients’ recruitment, clinical examination and clinical data acquisition: Myasoedova VA, Kirichenko TV,
Orekhova VA, Grechko AV
MtDNA genotyping: Khasanova ZB, Sinyov VV, Melnichenko AA
Concept elaboration, general coordination and discussion: Orekhov AN

Availability of data and materials
Not applicable.

Financial support and sponsorship
The study was supported by the Russian Science Foundation (19-15-00297).

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethics approval and consent to participate
This study was kept in accordance with the Helsinki Declaration of 1975 as revised in 1983, 2008 and
2013. It was approved by the local ethics committee of the Institute for Atherosclerosis Research, Skolkovo
Innovation Center, Moscow, Russia. All participants gave their written informed consent prior to their
inclusion in the study.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

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