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Strokova et al. Vessel Plus 2019;3:16 Vessel Plus
DOI: 10.20517/2574-1209.2019.08

Original Article Open Access

Lipid profile of children with glycogen storage
disease

Tatyana Victorovna Strokova , Elena Vyacheslavovna Pavlovskaya , Andrey Igorevich Zubovich , Yurgita
1
1
1
Ruslanovna Varaeva , Natalia Valerievna Polenova , Elena Nikolaevna Livantsova , Madlena Enverovna
1
1
1
Bagaeva , Alexander Gennadievich Surkov , Svetlana Dmitrievna Kosyura , Antonina Vladimirovna
1
1,2
1
Starodubova 1,2
1 Department of Pediatric Gastroenterology, Hepatology and Nutrition, Nutrition Clinic of Federal Research Centre of Nutrition,
Biotechnology and Food Safety, Moscow 115446, Russia.
2 Department of Personalized Therapy and Nutrition, Nutrition Clinic of Federal Research Centre of Nutrition, Biotechnology and
Food Safety, Moscow 115446, Russia.
Correspondence to: Dr. Yurgita Ruslanovna Varaeva, Junior Research Fellow of Department of Personalized Therapy and
Nutrition, Nutrition Clinic of Federal Research Centre of Nutrition, Biotechnology and Food Safety, Kasirskoe shosse 21, Moscow
115446, Russia. E-mail: yurgitavaraeava@gmail.com
How to cite this article: Strokova TV, Pavlovskaya EV, Zubovich AI, Varaeva YR, Polenova NV, Livantsova EN, Bagaeva ME,
Surkov AG, Kosyura SD, Starodubova AV. Lipid profile of children with glycogen storage disease. Vessel Plus 2019;3:16.
http://dx.doi.org/10.20517/2574-1209.2019.08

Received: 3 Dec 2018 First Decision: 5 Feb 2019 Revised: 11 Feb 2019 Accepted: 12 Feb 2019 Published: 10 May 2019

Science Editor: Alexander N. Orekhov Copy Editor: Cai-Hong Wang Production Editor: Huan-Liang Wu

Abstract
Aim: To determine the lipid profile patterns in children with different types of glycogen storage disease (GSD).

Methods: The study included 62 children with GSD (43 boys, 19 girls), mean age 8.29 years. All patients underwent
anthropometry, assessment of physical development, lipid profile analysis.

Results: The children were divided into three groups depending on the type of GSD. Nineteen children (31%) had type I
GSD (Group 1), 16 (26%) - type III (Group 2) and 27 (43%) - types VI and IX (Group 3). Dyslipidemia of varying severity
was more specific to patients with type I and III GSD. Higher levels of triglycerides were associated with type I GSD, while
higher levels of LDL cholesterol were common to type III GSD (P < 0.05) No changes in the lipid profile were observed in
18 (29%): one with type I, 4 with type III, and 13 with types VI and IX.

Conclusion: Lipid metabolism disorders were detected in 71% of children with GSD, especially with types I and III. The
elevated levels of total cholesterol and LDL cholesterol are associated with the early progression of atherosclerosis and an
increased cardiovascular risk in the general population. But there is a lack of evidence of a link between lipid metabolism

© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

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