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Page 8 of 9 Nemtsova et al. Vessel Plus 2018;2:27 I http://dx.doi.org/10.20517/2574-1209.2018.48

In our study, we observed not only an increase in this index in patients with HT and T2DM compared
to the control group, but there was also an age-associated increase in the average 8-OH-dG in the 2b age
[20]
group, which coincides with the results of Wang et al. , who demonstrated a significant relationship
between the plasma level of 8-OHdG and the age of the studied subjects.

Our results indicate that the combined course of HT and T2DM is characterized by the presence of pronounced
oxidative stress, which manifests in a significant increase in the intensity of lipid peroxidation, the marker of
DNA damage which increased against the background of a decreased activity of antioxidant protection.

Despite the fact that the age-associated changes in oxidative stress in comorbid course of HT and T2DM
did not have significant differences, the presence of correlations between various indexes that are included
in the concept of “vascular aging” and indicators of oxidant-antioxidant systems in different age groups
allows us to make an assumption about the significant influence of the oxidative status on the status of VA,
especially in the older age group persons.

Given that elderly age is generally characterized by polymorbidity and with age the risk of age-associated
diseases development, including HT and T2DM and their complications, increases, one active area of
research is to study the peculiarities of oxidative stress development in older age groups.

Thus, to date the concept of VA allows us to take a new view at the assessment of CVR: on the one hand,
as a biological model of aging, on the other, it makes it possible to analyze the state of many risk factors in
different age groups.

DECLARATIONS
Authors’ contributions
Study design, manuscript review: Nemtsova V, Bilovol O
Development of methodology: Nemtsova V
Collection of data, analysis and/or interpretation of data, writing (not revising) all or sections of the
manuscript: Nemtsova V, Bilovol O, Ilchenko I, Shalimova A
Supervision: Bilovol O

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
All authors declared that there were no conflicts of interest.

Ethical approval and consent to participate
The study protocol was supported by the Ethics Committee of the Kharkiv National Medical University,
Ukraine.

Consent for publication
Each patient was informed the study and gave their consent.

Copyright
© The Author(s) 2018.