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Nemtsova et al. Vessel Plus 2018;2:27 Vessel Plus
DOI: 10.20517/2574-1209.2018.48

Original Article Open Access

Age-associated features of oxidative stress as
marker of vascular aging in comorbid course of
hypertension and type 2 diabetes mellitus

Valeriya Nemtsova , Olexander Bilovol , Irina Ilchenko , Anna Shalimova 2
1
1
1
1 The Clinical Pharmacology and Internal Diseases Department, Kharkiv National Medical University, Kharkiv 61039, Ukraine.
2 Department of Chronic Non-communicable Disease Prevention, Government Institution “National Institute of Therapy named
by L.T. Malaya of National Ukrainian Academy of Medical Science”, Kharkiv 61039, Ukraine.
Correspondence to: Dr. Anna Shalimova, Department of Chronic Non-communicable Disease Prevention, Government
Institution “National Institute of Therapy named by L.T. Malaya of National Ukrainian Academy of Medical Science”, Kharkiv,
61039, Ukraine. E-mail: anna.shalimova83@gmail.com

How to cite this article: Nemtsova V, Bilovol O, Ilchenko I, Shalimova A. Age-associated features of oxidative stress as marker of
vascular aging in comorbid course of hypertension and type 2 diabetes mellitus. Vessel Plus 2018;2:27.
http://dx.doi.org/10.20517/2574-1209.2018.48
Received: 25 Jun 2018 First Decision: 27 Jul 2018 Revised: 8 Aug 2018 Accepted: 31 Aug 2018 Published: 28 Sep 2018
Science Editor: Igor A. Sobenin Copy Editor: Cui Yu Production Editor: Zhong-Yu Guo

Abstract
Aim: To evaluate activity of oxidative stress (OS) as marker of vascular aging in different age groups of patients with
combined course of arterial hypertension (HT) and type 2 diabetes mellitus (T2DM).

Methods: 126 patients (average age 57.8 ± 6.2 years) with stage II HT and compensated T2DM were divided into
2 subgroups: 2a (n = 59) - aged 45-60 years; 2b (n = 97) - aged 61-75 years; 30 patients with isolated stage II HT
(comparison group), 20 practically healthy individuals (control group). The activity of antioxidative [glutathione
peroxidase, sulfhydryl groups (SH-groups)] and oxidative [malonic dialdehyde (MDA)], 8-hydroxy-2-deoxyguanosine
(8-OH-dG) systems in blood serum, were studied.

Results: A significant increase in MDA levels (P < 0.05) and SH-groups (P < 0.05) compared with healthy volunteers
was observed. Patients in 2b group had lower MDA values than in 2a (6.25 ± 0.33 μmol/L, 7.07 ± 0.44 μmol/L,
respectively, P > 0.05). In the 2b group, in comparison with 2a patients, a decrease in thiol status was observed (P > 0.05).
The level of 8-OH-dG was increased in patients with HT and T2DM, but there was also an age-associated increase in
the average 8-OH-dG in the 2b group.

Conclusion: The age-associated changes in the OS in comorbid course of HT and T2DM did not have significant
differences. Nevertheless, the presence of correlations between various indexes that are included in the concept of “vascular

© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0
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