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Page 4 of 14               Abdel-Halim et al. Vessel Plus 2022;6:8  https://dx.doi.org/10.20517/2574-1209.2021.40




































                Figure 2. Photomicrograph depicting large zones of necrobiosis/necrosis in the dermis from a case of granulomatosis with polyangiitis
                (H&E, original magnification 40×) (courtesy of the Dermatopathology Unit, Dermatology Department, Cairo University).




























                Figure 3. Photomicrograph depicting features of palisaded neutrophilic and granulomatous dermatitis in a case of granulomatosis with
                polyangiitis: interstitial histiocytes and neutrophils as well as foci of necrobiotic collagen (H&E, original magnification 100×).

               Rare or unusual clinical presentations of vasculitic skin lesions in AAV
               GPA patients may develop pyoderma gangrenosum (PG)-like ulcers characterized by being large, intensely
               painful with undermined edges [8,21,22] . Several pediatric cases of GPA have been reported with PG-like ulcers
               mainly presenting on the face as the initial presenting manifestation of the disease. This can even precede
               the classic systemic symptoms [23-27]  [Figure 9]. Localized variants of GPA may present with long standing
               recalcitrant ulcerative skin lesions mainly localized to the face and upper respiratory tract mucosa [28,29] .
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