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this reason, efforts to try to correct any specific dysregulated angiogenic signaling, rooted from deficiency in
any CCMs, to alleviate CCM lesion burden or even prevent hemorrhagic CCMs might eventually prove to
be too little too late [Figure 1].

DECLARATIONS
Authors’ contributions
Conceptualization, methodology, writing original draft preparation, reviewing and editing: Zhang J
Writing, reviewing and editing: Abou-Fadel JS

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
Both authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2021.

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