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Page 10 of 14 Broadwin et al. Vessel Plus 2023;7:25 https://dx.doi.org/10.20517/2574-1209.2023.103

Figure 5. Measures of myocardial perfusion between 4 groups. EV therapy was not associated with any significant alteration to blood
flow to ischemic myocardial territories under resting or paced conditions. Similarly, EV therapy was not associated with any significant
alteration to blood flow to non-ischemic myocardial territories under resting or paced conditions.

ischemia; however, more research is needed to determine this conclusively. Previous studies have shown
consistent alteration in the methylome of blood samples of patients with ACS [26,30] . It has been previously
established that MI can cause acute changes in the methylation pattern of DNA as early as 6 h post MI in
mouse models . Much like our enrichment analysis, prior studies have shown alteration in the biological
[8]
processes of immune system processes, and regulation of responses to stimuli and cell activation after
enrichment analysis . We observed alteration in the molecular function of sterol response element binding
[26]
and pathway analysis showed changes in regulation of lipid metabolism in our analysis. This is consistent
with this existing literature, which has shown enrichment in phospholipid, protein, and lipid binding
activities in patients with ACS .
[26]

Diet effect
[31]
There have been well-established links between cardiovascular risk and diet . This increased risk is
multifactorial. There has been a well-established effect of diet on DNA methylation, most notably the work
[32]
surrounding the individuals who survived the Dutch Famine and their offspring . More recently, small
animal models have shown alteration in the atherosclerotic response of hypercholesterolemic mice with