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Figure 2. Enrichment analysis of molecular pathways in (A) ischemia effect, (B) diet effect, (C) EV effect in normal diet, and (D) EV
effect in HFD.
altered epigenetic regulation with well-established changes in transcriptomic and proteomic profiles after
ischemic events [28,29] . However, little is known about the alteration of the myocardial tissue methylome in
response to ischemic stress. Given the extent to which the methylome has been shown to be altered in other
physiologic and pathophysiologic states, investigating the role of tissue-specific methylation in ischemic
cardiac tissue is of interest.
