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Page 6 of 13  Zahrai et al. Vessel Plus 2023;7:32  https://dx.doi.org/10.20517/2574-1209.2023.100



 cohort                                 complications; in-  Patients who underwent CABG within
          2-3                           hospital mortality  24 h were more likely to develop any
                                                          complications compared to those in 2-
          4-7                                             3 and 4-7 days groups, respectively
                                                          (OR = 1.22, 95% CI 1.05-1.41, and OR
                                                          = 1.18, 95% CI 1.01-1.36, respectively).
                                                          Differences in complications between
                                                          2-3 and 4-7 days groups were not
                                                          statistically significant (OR  =  0.97,
                                                          95% CI 0.85-1.11)

                                                          Odds of in-hospital mortality was
                                                          higher in the < 1 day, compared to 2-3
                                                          days group (OR  =  1.85, 95% CI 1.52-
                                                          2.25) and 4-7 days group (OR  =  2.21,
                                                          95% CI 1.82-2.68). The latter two
                                                          groups did not differ in terms of in-
                                                          hospital mortality
 Liakopoulos  Prospective   STEMI,   618 STEMI   CABG of any type  STEMI: 68.3 ±   < 1   In-hospital all-
 et al.   registry cohort NSTEMI     10.3      cause mortality  In-hospital mortality occurred two-
 [38]
 (2020)  1,218 NSTEMI     1-3                             fold higher in STEMI patients who had
 NSTEMI: 66.6 ±                                           CABG < 24 h compared both to those
 11.3     > 3                                             who had CABG > 72 h and to those
                                                          between 24-72 h

                                                          CABG timing did not affect the in-
                                                          hospital mortality of patients with
                                                          unstable angina or those with NSTEMI

 Bianco et al.  Retrospective  STEMI   368 STEMI   Isolated CABG  66.0 (Range   < 1   All-cause
 [40]
 (2021)  cohort        58.0-74.0)       mortality         All-cause mortality postop was
 NSTEMI  1,690 NSTEMI  > 1                                significantly higher < 1 day, compared
                                                          to the > 1 day group[Hazard ratio (HR)
                                                          (95% CI) = 0.63 (0.42-0.97)]. After
                                                          risk factor adjustments, there was no
                                                          difference in terms of mortality
                                                          (4.15% vs. 4.58%, P = 0 .62). Timing
                                                          of CABG did not impact mortality in
                                                          either STEMI (HR = 0.57 (0.25-1.29)
                                                          or NSTEMI (HR = 0.99 (0.56-1.76))
                                                          groups

 Lang et al.   Systematic   STEMI   38,469 STEMI   CABG of any type  STEMI: 63.7      In-hospital   OR between < 24 h CABG and > 24 h
 [34]
 (2022)  review and            Many subdivisions ranging from   mortality  CABG groups was 2.65 (95% CI:
 meta-analysis  NSTEMI   3,405 NSTEMI   NSTEMI: 67.2   < 0.25 to 15-30 (STEMI)   1.96-3.58). This was 3.88 (2.69-5.60)
          < 1 to 3-21 (NSTEMI)                            for undefined STEMI/NSTEMI, 2.62
 Undefined   72,675 Undefined   Undefined   < 2 to > 42 (Undefined   (1.58-4.35) for STEMI, and 1.24 (0.83-
 STEMI/NSTEMI STEMI/NSTEMI  STEMI/NSTEMI:  STEMI/NSTEMI)  1.85) for NSTEMI groups
 65.9
                                                          OR between < 48 h CABG and > 48 h
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