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Zahrai et al. Vessel Plus 2023;7:32  https://dx.doi.org/10.20517/2574-1209.2023.100   Page 5 of 13


 Table 3. Summary of the studies included

 First   Mean age ±                     Primary
 author   Study design MI type  Number of patients  Intervention(s)  SD (years)  Time to CABG (days)  outcome(s)  Main results
 (year)

 Sintek, et al.  Retrospective  STEMI, NSTEMI 2,175 (1,013 STEMI, # of  Isolated CABG  63.4 (Range 32-  < 1   30-day operative   Timing of surgery
 [41]
 (1994)  cohort  NSTEMI not specified)  85)     mortality  was not significantly associated with
          1-2                                             operative mortality

          2-3

          3-7

          7-30
 Thielmann   Retrospective  STEMI  138  Primary isolated   65.6 ± 10.8  < 0.25   All-cause in-
 et al.   cohort  CABG                  hospital mortality  Patients who underwent CABG
 [39]
 (2007)   0.25-1                                          between 7-23 h (after symptom
                                                          onset) had significantly higher
          1-3                                             mortality rate than those in the 4-7
                                                          days [vs. 7-23 h group: OR = 0.5 (95%
          4-7                                             CI 0.3-0.8)] or 8-14 days groups [7-
                                                          23 h vs. 8-14 days: OR = 3.4 (1.7-21.3)]
          8-14
 Weiss et al.  Retrospective  AMI type not   9,476  CABG of any type  67.6 ± 11.0  < 2   All-cause hospital
 [7]
 (2008)  cohort  specified              mortality         Early CABG (0-2 days) was an
          > 2                                             independent predictor of hospital
                                                          mortality (OR = 1.40, 95% CI: 1.12-
                                                          1.74)

                                                          Surgical delay beyond 3 days did not
                                                          provide any further survival benefit
 Parikh et al.  Retrospective  NSTEMI  2,647  CABG of any type  64.0  < 2   Composite of
 [45]
 (2010)  cohort                         death, MI,        NSTEMI patients undergoing early and
          > 2                           cardiogenic shock,  late CABG had similar in-hospital
                                        or congestive heart  mortality (OR = 1.12, 95% CI: 0.71-
                                        failure           1.78) and composite outcome (OR =
                                                          0.94, 0.69-1.28) occurrences
 Chen et al.   Meta-analysis     100,048  CABG of any type  Not specified  Many sub-divisions ranging from   In-hospital   There was an increase in in-hospital
 [33]
 (2014)  of 12 studies  STEMI (3   < 0.25 to > 43  mortality between  mortality of 0.950 (95% CI 0.936-
 studies                                different CABG    0.964) for each day delay to CABG
                                        time intervals after  after acute MI and 0.774 (95% CI
 NSTEMI (1                              AMI               0.719-0.834) for each 5 day increase
 study)

 STEMI/NSTEMI
 (8 studies)
 Lemaire et al.    Retrospective  STEMI  5,963  CABG of any type  63.1 ± 11.1  < 1   Postoperative
 [37]
 (2020)
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